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ChemicalBook >> CAS DataBase List >> 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one price.
  • $55 - $1755
  • Product name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
  • CAS: 5627-05-4
  • MF: C9H14N2O6
  • MW: 246.22
  • EINECS:
  • MDL Number:MFCD00047490
  • Synonyms:1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one;Uridine, 5,6-dihydro-;Uridine Impurity 28（5,6-Dihydrouridine）;6-Dihydrouridine;5,6-Dihydrouridine RNA-modified nucleoside D;dihydrouridine;1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione;5,6-Dihydrouridine, 10 mM in DMSO
5 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ChemScene
  • SynQuest Laboratories
  • TRC
Package
  • 5MG
  • 100mg
  • 250mg
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberNUC0001384
  • Product description5,6-DIHYDRO-URIDINE 95.00%
  • Packaging5MG
  • Price$501.22
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0059431
  • Product description5,6-Dihydrouridine 99.87%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerSynQuest Laboratories
  • Product number4H12-1-03
  • Product description5,6-Dihydrouridine 95%
  • Packaging250mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD449668
  • Product description5,6-Dihydrouridine
  • Packaging100mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD449668
  • Product description5,6-Dihydrouridine
  • Packaging250mg
  • Price$1755
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation NUC0001384 5,6-DIHYDRO-URIDINE 95.00% 5MG $501.22 2021-12-16 Buy
ChemScene CS-0059431 5,6-Dihydrouridine 99.87% 5mg $120 2021-12-16 Buy
SynQuest Laboratories 4H12-1-03 5,6-Dihydrouridine 95% 250mg $55 2021-12-16 Buy
TRC D449668 5,6-Dihydrouridine 100mg $800 2021-12-16 Buy
TRC D449668 5,6-Dihydrouridine 250mg $1755 2021-12-16 Buy

Properties

Density :1.614±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
form :A crystalline solid
pka :12.40±0.20(Predicted)
color :White to off-white
PH :～11
λmax :208 (in H2O)
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.