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ChemicalBook >> CAS DataBase List >> FLAVOPIRIDOL HYDROCHLORIDE

FLAVOPIRIDOL HYDROCHLORIDE

FLAVOPIRIDOL HYDROCHLORIDE price.
  • $27 - $2220
  • Product name: FLAVOPIRIDOL HYDROCHLORIDE
  • CAS: 131740-09-5
  • MF: C21H21Cl2NO5
  • MW: 438.3
  • EINECS:634-346-4
  • MDL Number:MFCD26792554
  • Synonyms:Flavopiridol (Alvocidib)hcl;Flavopiridol HCI;L-86-8276;2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride;NSC 649890 HCl;(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride Flavopiridol hydrochloride;Flavopiridol hydrochloride (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride;Flavopiridol hydrochloride, >=98%
43 prices
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  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
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  • Biosynth Carbosynth
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  • ManufacturerAmbeed
  • Product numberA180731
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+%
  • Packaging1mg
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA180731
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+%
  • Packaging5mg
  • Price$46
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA180731
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+%
  • Packaging10mg
  • Price$64
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA180731
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+%
  • Packaging50mg
  • Price$179
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA180731
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+%
  • Packaging100mg
  • Price$357
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA180731
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+%
  • Packaging250mg
  • Price$687
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA180731
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+%
  • Packaging1g
  • Price$1717
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001299
  • Product descriptionFLAVOPIRIDOL HYDROCHLORIDE 95.00%
  • Packaging10MG
  • Price$739.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001299
  • Product descriptionFLAVOPIRIDOL HYDROCHLORIDE 95.00%
  • Packaging100MG
  • Price$1871.1
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8640
  • Product descriptionFlavopiridolhydrochloride
  • Packaging25mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025647
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98%
  • Packaging1mg
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025647
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98%
  • Packaging5mg
  • Price$46
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025647
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98%
  • Packaging10mg
  • Price$63
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025647
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98%
  • Packaging50mg
  • Price$177
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60283
  • Product descriptionFlavopiridolHC ≥98%
  • Packaging20mg
  • Price$288
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025647
  • Product description2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98%
  • Packaging100mg
  • Price$353
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A180731 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+% 1mg $27 2021-12-16 Buy
Ambeed A180731 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+% 5mg $46 2021-12-16 Buy
Ambeed A180731 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+% 10mg $64 2021-12-16 Buy
Ambeed A180731 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+% 50mg $179 2021-12-16 Buy
Ambeed A180731 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+% 100mg $357 2021-12-16 Buy
Ambeed A180731 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+% 250mg $687 2021-12-16 Buy
Ambeed A180731 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride 98+% 1g $1717 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001299 FLAVOPIRIDOL HYDROCHLORIDE 95.00% 10MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001299 FLAVOPIRIDOL HYDROCHLORIDE 95.00% 100MG $1871.1 2021-12-16 Buy
ApexBio Technology A8640 Flavopiridolhydrochloride 25mg $100 2021-12-16 Buy
Arctom AS025647 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98% 1mg $27 2021-12-16 Buy
Arctom AS025647 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98% 5mg $46 2021-12-16 Buy
Arctom AS025647 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98% 10mg $63 2021-12-16 Buy
Arctom AS025647 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98% 50mg $177 2021-12-16 Buy
Arctom CFN60283 FlavopiridolHC ≥98% 20mg $288 2021-12-16 Buy
Arctom AS025647 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-onehydrochloride ≥98% 100mg $353 2021-12-16 Buy

Properties

Melting point :169.5-170°C
alpha :24D -1.73 to -3.9°
storage temp. :2-8°C
solubility :H2O: ~2mg/mL
pka :5.68 ± 0.06(at 25℃)
form :powder
color :white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
CAS DataBase Reference :131740-09-5

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Flavopiridol is a synthetic flavonoid based on an extract from Dysoxylum binectariferum which has shown potential for treatment of cancer in vitro. Flavopiridol hydrochloride is a potent inhibitor of cyclin-dependent kinases (primarily Cdk1, Cdk2, and Cdk4) with an IC50 of 100 nM. The (-)-cis form induces apoptosis in particular tumor cells. At nanomolar concentrations, flavoporidol hydrochloride has been shown to reduce rhabdoid cell growth with an IC50 ranging from 50 to 200 nM. Treatment of flavopiridol decreased the activities of Cdk2 and potently prevented cell proliferation with an IC50 ranging from 43 to 83 nM in HNSCC cells.

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