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ChemicalBook >> CAS DataBase List >> 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID price.
  • $32 - $1949.9
  • Product name: 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID
  • CAS: 102121-60-8
  • MF: C22H25NO3
  • MW: 351.44
  • EINECS:
  • MDL Number:MFCD00673916
  • Synonyms:4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid;NSC 608001;4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid;benzoicacid,4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbony ;cd336 ;l)amino- ;ro40-6055 ;AM 580
41 prices
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Brand
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 10
  • 1MG
  • 10mg
  • 50
  • 25mg
  • 50MG
  • 100mg
  • 250mg
  • 10mM(in 1mL DMSO)
  • 1000mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3437AH
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoicacid
  • Packaging5mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ65155
  • Product descriptionAM 580
  • Packaging10mg
  • Price$131.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008429
  • Product descriptionAM 580 95.00%
  • Packaging1MG
  • Price$135.45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008429
  • Product descriptionAM 580 95.00%
  • Packaging10MG
  • Price$697.34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008429
  • Product descriptionAM 580 95.00%
  • Packaging50MG
  • Price$1170.31
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4654
  • Product descriptionAM 580
  • Packaging10mM(in 1mL DMSO)
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4654
  • Product descriptionAM 580
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4654
  • Product descriptionAM 580
  • Packaging50mg
  • Price$361
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS467988
  • Product descriptionAM 580 ≥98%
  • Packaging100mg
  • Price$194
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180917
  • Product descriptionAM 580 >98%
  • Packaging100mg
  • Price$542.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180917
  • Product descriptionAM 580 >98%
  • Packaging250mg
  • Price$986
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180917
  • Product descriptionAM 580 >98%
  • Packaging1000mg
  • Price$1949.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137469
  • Product descriptionAM 580
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA137469
  • Product descriptionAM 580
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15261
  • Product descriptionAM 580 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15261
  • Product descriptionAM 580 ≥98%
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3437AH 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoicacid 5mg $150 2021-12-16 Buy
Alfa Aesar J65155 AM 580 10mg $131.65 2024-03-01 Buy
American Custom Chemicals Corporation API0008429 AM 580 95.00% 1MG $135.45 2021-12-16 Buy
American Custom Chemicals Corporation API0008429 AM 580 95.00% 10MG $697.34 2021-12-16 Buy
American Custom Chemicals Corporation API0008429 AM 580 95.00% 50MG $1170.31 2021-12-16 Buy
ApexBio Technology B4654 AM 580 10mM(in 1mL DMSO) $75 2021-12-16 Buy
ApexBio Technology B4654 AM 580 10mg $100 2021-12-16 Buy
ApexBio Technology B4654 AM 580 50mg $361 2021-12-16 Buy
Arctom AS467988 AM 580 ≥98% 100mg $194 2021-12-16 Buy
Biorbyt Ltd orb180917 AM 580 >98% 100mg $542.3 2021-12-16 Buy
Biorbyt Ltd orb180917 AM 580 >98% 250mg $986 2021-12-16 Buy
Biorbyt Ltd orb180917 AM 580 >98% 1000mg $1949.9 2021-12-16 Buy
Biosynth Carbosynth FA137469 AM 580 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FA137469 AM 580 50mg $437.5 2021-12-16 Buy
Cayman Chemical 15261 AM 580 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 15261 AM 580 ≥98% 5mg $93 2024-03-01 Buy

Properties

Melting point :265-267℃
Boiling point :485.24°C (rough estimate)
Density :1.154
refractive index :1.5614 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).
form :White to off-white solid.
pka :4.28±0.10(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

AM580 is a retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM). It demonstrates greater specific binding to RARα compared to retinoic acid , which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm. It can also inhibit the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.

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