Ivacaftor suppliers
Ivacaftor
- CAS:
- 873054-44-5
- MF:
- C24H28N2O3
- MW:
- 392.49
Suppliers by country/region
Company Type
Properties
- Melting point:
- 212-215°C
- Boiling point:
- 550.4±50.0 °C(Predicted)
- Density
- 1.187
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 11.08±0.23(Predicted)
- form
- Solid
- color
- White to Light Brown
- InChI
- InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
- InChIKey
- PURKAOJPTOLRMP-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C(=O)C(C(NC2=CC(O)=C(C(C)(C)C)C=C2C(C)(C)C)=O)=C1
Safety Information
- Symbol(GHS)
GHS08,GHS07
- Signal word
- Warning
- Hazard statements
- H361-H319-H315-H335
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P
- HS Code
- 29333990
Use
In January 2012, the US FDA approved ivacaftor for the treatment of cystic fibrosis (CF) in patients who have the G551D mutation of the CF transmembrane regulator (CFTR) and are at least 6 years old. Ivacaftor (also known as VX-770) is a CFTR potentiator that increases the open probability of CFTR, thus increasing chloride secretion particularly in the 5% of CF patients with the G551D/F508 gating/ processing mutation. Ivacaftor was discovered by medicinal chemistry optimization of a lead scaffold identified through high-throughput screening of a 228,000 compound collection. In cultured bronchial epithelial cells from a CF patient with F508del, ivacaftor increased chloride secretion (EC50=81 nM). Preparation of ivacaftor is accomplished via a multistep synthesis oftwointermediates, 4-oxo-1,4-dihydroquinoline-3-carboxylic acid and 5-amino-di-tert-butylphenyl methyl carbonate, which are coupled using propane phosphonic acid anhydride (T3P) to afford the amide; deprotection of the phenol then provides ivacaftor.
211 supplier list of "Ivacaftor"
- Product Name:Ivacaftor (VX-770)
- Products Intro:Purity: 99.5%+ | Package: 1kg;10kg;25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Dantrolene Sodium,Mitotane,Crizotinib,Olaparib,Trametinib
- Product Name:Ivacaftor
- Products Intro:Purity: 99% | Package: 1g/Bag;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Orforglipron,Upadacitinib,Zasocitinib(TAK-279),AGM650
$0.00/ 1g
- Product Name:Ivacaftor
- Products Intro:Purity: More Than 99% | Package: 1g
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical Chemicals,Apis,Pharmaceutical Intermediates,Electronic Chemicals,OLED Intermediates
- Product Name:VX-770
- Products Intro:Purity: 0.98 | Package: 100KG;10KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:ivacaftor
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Ivacaftor(VX 770)
- Products Intro:Purity: As COA | Package: As request | CustNote: 873054-44-5
- Company Type: Trader
- Country/Region: CHINA
- Product Name:VX-770
- Products Intro:Purity: 0.99 | Package: 5MG;10MG;50MG;100MG,1G,5G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Ivacaftor
- Products Intro:Purity: 98% | Package: 1g | CustNote: BOC Sciences also provides custom synthesis services for Ivacaftor.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Ivacaftor
- Products Intro:Purity: 95%+ | Package: 5g;50g;100g;250g;500g;1kg;5kg
- Company Type: Trader
- Country/Region: CHINA