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CLASTO-LACTACYSTIN BETA-LACTONE

CLASTO-LACTACYSTIN BETA-LACTONE ??? ???
?? ??:
154226-60-5
???:
CLASTO-LACTACYSTIN BETA-LACTONE
???(??):
OMURALIDE;BETA-CLASTOLACTACYSTIN;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);CLASTO-LACTACYSTIN BETA-LACTONE;LACTACYSTIN, CLASTO-, BETA-LACTONE;clasto-Lactacystin beta-lactone, 20S proteasome inhibitor;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione;6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
CBNumber:
CB9352564
???:
C10H15NO4
??? ??:
213.23
MOL ??:
154226-60-5.mol
MSDS ??:
SDS

CLASTO-LACTACYSTIN BETA-LACTONE ??

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186-187°C
?? ??
-20°C
???
DMF, ???, ? ?? ?????, ???, ???? ???
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 20/21/22-37/38-41-36/37/38-25
????? 16-26-36/37/39-45
????(UN No.) UN 2811 6.1 / PGIII
WGK ?? 2
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
NFPA 704
3
2 0

CLASTO-LACTACYSTIN BETA-LACTONE C??? ??, ??, ??

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White Solid

??

A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.

Biochem/physiol Actions

Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.

CLASTO-LACTACYSTIN BETA-LACTONE ?? ?? ? ???

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CLASTO-LACTACYSTIN BETA-LACTONE ?? ??

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