ChemicalBook >?? ???? >CLASTO-LACTACYSTIN BETA-LACTONE
CLASTO-LACTACYSTIN BETA-LACTONE
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CLASTO-LACTACYSTIN BETA-LACTONE ??
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- 186-187°C
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- -20°C
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??? ?? | T | ||
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?? ???? ?? | 20/21/22-37/38-41-36/37/38-25 | ||
????? | 16-26-36/37/39-45 | ||
????(UN No.) | UN 2811 6.1 / PGIII | ||
WGK ?? | 2 |
CLASTO-LACTACYSTIN BETA-LACTONE C??? ??, ??, ??
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A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.Biochem/physiol Actions
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.CLASTO-LACTACYSTIN BETA-LACTONE ?? ?? ? ???
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CLASTO-LACTACYSTIN BETA-LACTONE ?? ??
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CLASTO-LACTACYSTIN BETA-LACTONE ?? ??:
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