ピランテルパモ酸塩 化學(xué)特性,用途語,生産方法
外観
うすい黃色～黃色, 結(jié)晶性粉末～粉末
溶解性
ジメチルホルムアミドにやや溶けにくい。メタノール、及びエタノールに極めて溶けにくい。水、酢酸エチル、エーテル及びクロロホルムにほとんど溶けない。エタノール(95)に極めて溶けにくく、水にほとんど溶けない。
用途
動(dòng)物用醫(yī)薬品定量用の標(biāo)準(zhǔn)品。
効能
駆蟲薬
商品名
コンバントリン (佐藤製薬); コンバントリン (佐藤製薬)
化學(xué)的特性
Pale yellow or yellow powder.
使用
An antiparasitic agent used in the treatment of intestinal parasites such as hookworms and roundworms (Ascaris lumbricoides, aka ascarids in humans) in domesticated animals such as horses, cattle, sheep, pigs, cats, dogs, and many other species.
適応癥
Pyrantel pamoate (Antiminth) is a agonist at the nicotinic
acetylcholine receptor, and its actions result in depolarization
and spastic paralysis of the helminth muscle.
Its selective toxicity occurs primarily because the
neuromuscular junction of helminth muscle is more
sensitive to the drug than is mammalian muscle. This
drug is administered orally, and because very little is absorbed,
high levels are achieved in the intestinal tract.
Less than 15% of the drug and its metabolites are excreted
in urine.
一般的な説明
Odorless light yellow to tan crystalline powder. Tasteless. Used medicinally against nematodes in animals.
空気と水の反応
May be sensitive to prolonged exposure to air and light . Insoluble in water.
反応プロフィール
Pyrantel pamoate may react with acids to liberate heat. May react exothermically enough with strong oxidizing acids to ignite the reaction products. Heat is also generated with caustic solutions. Generates flammable or toxic gases with alkali metals and hydrides and other reducing agents.
火災(zāi)危険
Flash point data for Pyrantel pamoate are not available; however, Pyrantel pamoate is probably combustible.
臨床応用
Trans-1,4,5,6,-Tetrahydro-1-methyl-2-[2-(2 -thienyl)ethenyl]pyrimidine pamoate (Antiminth) is a depolarizing neuromuscularblocking agent that causes spastic paralysis insusceptible helminths. It is used in the treatment of infestationscaused by pinworms and roundworms (ascariasis).Because its action opposes that of piperazine, the twoanthelmintics should not be used together. More than halfof the oral dose is excreted in the feces unchanged.Adverse effects associated with its use are primarilygastrointestinal.
副作用
Pyrantel pamoate is active against several roundworms:
A. lumbricoides, Ancylostoma duodenale, Necator
americanus, and E. vermicularis. Pyrantel is an alternative
drug of choice in treating infections with A. lumbricoides,
E. vermicularis (pinworms), and hookworms
(N. americanus and A. duodenale). It is not recommended
for pregnant patients or for children under age
1 year.
Although most of the drug remains in the intestinal
lumen, enough can be absorbed systemically to cause
headache, dizziness, and drowsiness. No major adverse
effects have been reported on renal, hepatic, or hematological
systems.
ピランテルパモ酸塩 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品