ぎ酸 メチル 化學(xué)特性,用途語,生産方法
外観
無色～ほとんど無色透明液體
外観
無色透明液體
用途
ぎ酸、ホルムアミド、酢酸、DMFなどの基礎(chǔ)化學(xué)品、香料及び溶剤、鋳型及び中子製造時の硬化剤、発泡剤及びスプレー剤、一酸化炭素発生源
説明
Methyl Formate, also known as methyl methanoate, is the methyl ester of formic acid. The simplest example of an ester, it is a clear liquid with an ethereal odour, high vapor pressure, and low surface tension. It is an aromatic compound found in apples (Neubeller and Buchloh, 1986), and was identified as a volatile constituent in brewed, roasted, and dried coffee (Lovell et al., 1980); Methyl formate is used primarily to manufacture formamide, dimethylformamide, and formic acid. It is also used as a solvent for quick-drying finishes such as lacquers and in organic synthesis.
化學(xué)的特性
Methyl formate is a colorless liquid with a pleasant odor. Its solubility in water is 230 g/l at 25 °C (Riddick et al., 1985), but it reacts slowly with water to form formic acid and methyl alcohol (DOT, 1984). It is soluble in ether, chloroform, and is miscible with ethanol (Lide, 2000).
物理的性質(zhì)
Clear, colorless, mobile liquid with a pleasant, etheral odor. An odor threshold concentration of
130 ppm
v was reported by Nagata and Takeuchi (1990).
使用
Methyl formate is used as a fumigant, as alarvicide for food crops, and as a solvent forcellulose acetate.
調(diào)製方法
In the laboratory, methyl formate can be produced by the condensation reaction of methanol and formic acid, as follows:
HCOOH + CH
3OH → HCOOCH
3 + H
2O
Industrial methyl formate, however, is usually produced by the combination of methanol and carbon monoxide (carbonylation) in the presence of a strong base, such as sodium methoxide :
CH
3OH + CO → HCOOCH
3 This process, practiced commercially by BASF among other companies gives 96 % selectivity toward methyl formate, although it can suffer from catalyst sensitivity to water, which can be present in the carbon monoxide feedstock, commonly derived from synthesis gas. Very dry carbon monoxide is, therefore, an essential requirement.
定義
ChEBI: Methyl formate is a formate ester resulting from the formal condensation of formic acid with methanol. A low-boiling (31.5 ℃) colourless, flammable liquid, it has been used as a fumigant and larvicide for tobacco and food crops. It has a role as a polar aprotic solvent, a fumigant, an insecticide and a refrigerant. It is a formate ester, a methyl ester and a volatile organic compound. It is functionally related to a methanol.
一般的な説明
A clear colorless liquid with an agreeable odor. Flash point -27°F. Less dense than water Vapors heavier than air.
空気と水の反応
Highly flammable. Water soluble. Reacts slowly with water to give formic acid, a corrosive material, and methanol, a flammable liquid. Both products are dissolved in the water.
反応プロフィール
Methyl formate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides.
危険性
Flammable, dangerous fire and explosionrisk, explosive limits in air 5.9–20%. Eye, upperand lower respiratory tract irritant.
健康ハザード
Methyl formate is a moderately toxic com pound affecting eyes, respiratory tract, andcentral nervous system. It is an irritant tothe eyes, nose, and lungs. Exposure to highconcentrations of its vapors in air may pro duce visual disturbances, irritations, narcoticeffects, and respiratory distress in humans.Such effects may be manifested at a 1-hourexposure to about 10,000-ppm concentration.Cats died of pulmonary edema from 2-hourexposure to this concentration
The acute oral toxicity of methyl formatewas low in test subjects. The symptoms werenarcosis, visual disturbances, and dyspnea.An oral LD50 value in rabbit is in the range1600 mg/kg..
火災(zāi)危険
Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back.
化學(xué)性質(zhì)
ギ酸の加水分解によりギ酸を得るための中間體
安全性プロファイル
Moderately toxic by
ingestion. Inhalation of vapor can cause
irritation to nasal passages and conjunctiva,
optic neuritis, narcosis, retching, and death
from pulmonary irritation. Industrial
fatalities have occurred only with exposure
to high concentrations. Flammable liquid.
Very dangerous fire hazard when exposed to
heat or flame; can react vigorously with
oxidizing materials. Explosive in the form of
vapor when exposed to heat or flame.
Reacts with methanol + sodium methoxide
to form an explosive product. To fight fire,
use alcohol foam, CO2, dry chemical. When
heated to decomposition it emits acrid
smoke and irritating fumes.
職業(yè)ばく露
Methyl formate is used as a solvent;
as an intermediate in pharmaceutical manufacture; and
as a fumigant
環(huán)境運命予測
Photolytic. Methyl formate, formed from the irradiation of dimethyl ether in the presence of
chlorine, degraded to carbon dioxide, water, and small amounts of formic acid. Continued
irradiation degraded formic acid to carbon dioxide, water, and hydrogen chloride (Kallos and Tou,
1977; Good et al., 1999).
A rate constant of 2.27 x 10
-12 cm
3/molecule?sec was reported for the reaction of methyl formate
and OH radicals in the atmosphere (Atkinson, 1989).
Chemical/Physical. Hydrolyzes slowly in water forming methanol and formic acid (NIOSH,
1997). Hydrolysis half-lives reported at 25 °C: 0.91 h at pH 9, 9.1 h at pH 8, 2.19 d at pH 7, and
21.9 d at pH 6 (Mabey and Mill, 1978).
合成方法
ナトリウムメチラートが使用されるアルコリシス法で製造される。
純化方法
Wash the formate with strong aqueous Na2CO3, dry it with solid Na2CO3 and distil it from P2O5. (Procedure removes free alcohol or acid.) [Beilstein 2 IV 20.]
不和合性
May form explosive mixture with air.
Incompatible with oxidizers (chlorates, nitrates, peroxides,
permanganates, perchlorates, chlorine, bromine, fluorine,
etc.); contact may cause fires or explosions. Keep away
from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts slowly with water to form methanol
and formic acid. Contact with water, steam releases formic
acid. Compounds of the carboxyl group react with all
bases, both inorganic and organic (i.e., amines) releasing
substantial heat, water and a salt that may be harmful.
Incompatible with arsenic compounds (releases hydrogen
cyanide gas), diazo compounds, dithiocarbamates isocyanates, mercaptans, nitrides, and sulfides (releasing
heat, toxic, and possibly flammable gases), thiosulfates and
dithionites (releasing hydrogen sulfate and oxides of sulfur)
廃棄物の処理
Incineration; atomizing in a
suitable combustion chamber.
參考文獻
Lee, Jae S., J. C. Kim, and Y. G. Kim. "Methyl formate as a new building block in C1 chemistry." Applied Catalysis 57.1 (1990): 1-30.
Handa, Yash Paul, et al. "Insulating Thermoplastic Foams Made With Methyl Formate-Based Blowing Agents." (2006).
ぎ酸 メチル 上流と下流の製品情報
原材料
準備製品
3,5-ジブロモアントラニル酸メチル
6-フルオロ-3-ピリジンカルボキシアルデヒド
2-[[[[[4-エトキシ-6-(メチルアミノ)-1,3,5-トリアジン-2-イル]アミノ]カルボニル]アミノ]スルホニル]安息香酸メチル
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N,N-ジメチルホルムアミド
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2-[2-[4-[(4-ethoxyphenyl)methylamino]phenyl]vinyl]-5-(methoxycarbonyl)-1,3,3-trimethyl-3H-indolium chloride
N,N'-ビス(4-ニトロフェニル)尿素·4,6-ジメチル-2(1H)-ピリミドン
ぎ酸
2-[[[[(4-メトキシ-6-メチル-1,3,5-トリアジン-2-イル)(メチル)アミノ]カルボニル]アミノ]スルホニル]安息香酸メチル
5-メトキシ-2-(メチルスルファニル)-4-ピリミジノール
2,4-ジクロロ-5-メトキシピリミジン
1-ホルミルホモピペラジン
4-(アセチルアミノ)-5-クロロ-2-メトキシ安息香酸メチル
N-(3,5-ジクロロフェニル)-1,2-ジメチル-1,2-シクロプロパンジカルボキシミド
りん酸3,4-ジメチルピラゾール
1,4-ジホルミルピペラジン
2-メチルピリミジン-4-オール
2-ブロモ-5-チアゾールカルボキシアルデヒド 臭化物
ジクロロメチルメチルエーテル
4-クロロ-5-メトキシ-2-(メチルスルファニル)ピリミジン
5-メトキシ-2-スルファニル-4-ピリミジノール
N-ホルミルモルホリン
N-メチルホルムアミド
2-[[(4-メトキシ-6-メチル-1,3,5-トリアジン-2-イル)カルバモイル]スルファモイル]安息香酸メチル
3,5-DIFLUOROPYRIDINE-4-CARBALDEHYDE
5-エチル-2-チオウラシル
ホルムアミド