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XAP044

化學(xué)構(gòu)造式
196928-50-4
CAS番號.
196928-50-4
化學(xué)名:
別名:
英語名:
XAP044
英語別名:
XAP044;7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one;7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-;XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044
CBNumber:
CB73152769
化學(xué)式:
C15H9IO4
分子量:
380.13
MOL File:
196928-50-4.mol
MSDS File:
SDS

XAP044 物理性質(zhì)

沸點(diǎn) :
485.7±45.0 °C(Predicted)
比重(密度) :
1.853±0.06 g/cm3(Predicted)
貯蔵溫度 :
Store at -20°C
溶解性:
≤10mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
外見 :
crystalline solid
酸解離定數(shù)(Pka):
6.70±0.20(Predicted)

安全性情報

XAP044 価格 もっと(6)

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
富士フイルム和光純薬株式會社(wako) W01FLC511616
7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one 		196928-50-4 250mg ￥175600 2021-03-23 購入
富士フイルム和光純薬株式會社(wako) W01FLC511616
7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one 		196928-50-4 500mg ￥311900 2021-03-23 購入
富士フイルム和光純薬株式會社(wako) W01TOC5248
XAP 044 		196928-50-4 10mg ￥71000 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01TOC5248
XAP 044 		196928-50-4 50mg ￥300000 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01FLC511616
7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one 		196928-50-4 1g ￥553100 2021-03-23 購入

XAP044 化學(xué)特性,用途語,生産方法

説明

XAP044 is an antagonist of the metabotropic glutamate (mGlu) receptor 7 (mGluR7), inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM. This effect is absent in mGluR7-deficient mice. XAP044 demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.

使用

XAP 044 is a potent mGlu7 antagonist used in the treatment of anxiety and depression in mice (1,2). Applications towards stress, autism and drug abuse are also potential uses.

XAP044 上流と下流の製品情報

原材料

準(zhǔn)備製品

XAP044 生産企業(yè)

Global( 40)Suppliers
名前 電話番號 電子メール 國籍 製品カタログ 優(yōu)位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32002 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52925 58
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 14055 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Block Chemical Technology (Shanghai) Co., LTD 021-20432219 13918097649
 li_jinfei@acblock-lab.com China 9558 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11217 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551
 15151849396@163.com China 999 58
Energy Chemical 021-58432009 400-005-6266
 marketing1@energy-chemical.com China 44808 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8617 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24649 58

  スペクトルデータ(1HNMR)

  • 196928-50-4
  • XAP044
  • 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
  • 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)-
  • 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
  • XAP-044,mGlu7,XAP044,neurotransmission,brain exposure,CNS,inhibit,mGluR,antidepressant,Metabotropic glutamate receptors,wide spectrum,anti-stress,Inhibitor,anxiolytic-like,XAP 044
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