ストレプトクロリン
ストレプトクロリン 物理性質(zhì)
- 貯蔵溫度 :
- Store at -20°C
- 溶解性:
- DMSO: soluble; Methanol: soluble
- 外見 :
- A solid
- 色:
- Crystalline
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
ストレプトクロリン 価格
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購入 |
ストレプトクロリン 化學(xué)特性,用途語,生産方法
説明
Streptochlorin is a bacterial metabolite originally isolated from
Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).
使用
Streptochlorin is an antineoplastic agent and a potential chemotherapeutic agent for treating cholangiocarcinoma.
ストレプトクロリン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
ストレプトクロリン 生産企業(yè)
Global( 36)Suppliers
- 120191-51-7
- Streptochlorin
- 3-(4-Chloro-5-oxazolyl)-1H-indole
- Antibiotic SF 2583A
- SF 2583A
- 1H-Indole, 3-(4-chloro-5-oxazolyl)-
- 4-Chloro-5-(1H-indol-3-yl)oxazole
- 3-(4-クロロオキサゾール-5-イル)-1H-インドール
- ストレプトクロリン
- 3-(4-クロロ-5-オキサゾリル)-1H-インドール
- 3-(4-クロロ-1,3-オキサゾール-5-イル)-1H-インドール