テルミサルタン-D3 化學(xué)特性,用途語,生産方法
説明
Telmisartan-d
3 is intended for use as an internal standard for the quantification of telmisartan by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT
1 (K
i = 3.7 nM). It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (; EC
50 = 4.5 μM). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.
化學(xué)的特性
Off-White Crystalline Solid
使用
TelMisartan-d3 is an angiotensin II receptor antagonist.
テルミサルタン-D3 上流と下流の製品情報
原材料
準(zhǔn)備製品