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ヒドロキシクロロキン硫酸塩

ヒドロキシクロロキン硫酸塩 化學(xué)構(gòu)造式
747-36-4
CAS番號.
747-36-4
化學(xué)名:
ヒドロキシクロロキン硫酸塩
別名:
2-[[4-[(7-クロロキノリン-4-イル)アミノ]ペンチル]エチルアミノ]エタノール·硫酸塩;ヒドロキシクロロキン硫酸塩;硫酸ヒドロキシクロロキン;7-クロロ-4-[4-[N-エチル-N-(2-ヒドロキシエチル)アミノ]-1-メチルブチルアミノ]キノリン硫酸塩;N4-(7-クロロ-4-キノリル)-N1-エチル-N1-(2-ヒドロキシエチル)-1,4-ペンタンジアミン硫酸塩;ヒドロキシクロロキン 硫酸;ヒドロキシクロロキン硫酸塩 (JAN);2-[[4-[(7-クロロキノリン-4-イル)アミノ]ペンチル]エチルアミノ]エタノール?硫酸塩
英語名:
Hydroxychloroquine sulfate
英語別名:
HYDROXYCHLOROQUINE SULPHATE;Hydroxycloroquine sulfate;7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate;Quensyl;Ercoquin;Plaquinol;HCQ sulfate;plaquenilsulfate;Hydroxychloroquin;Acidum iopanoicum
CBNumber:
CB4423632
化學(xué)式:
C18H28ClN3O5S
分子量:
433.95
MOL File:
747-36-4.mol
MSDS File:
SDS

ヒドロキシクロロキン硫酸塩 物理性質(zhì)

融點(diǎn) :
240 °C
貯蔵溫度 :
protect from light
溶解性:
H2O: >20mg/mL
外見 :
結(jié)晶性粉末
色:
ホワイトからオフホワイト
PH:
3.5-5.5 (1% in aqueous solution, pH <6.0)
由來生物:
synthetic
水溶解度 :
溶けやすい
Merck :
14,4818
安定性::
購入日から2年間安定です。この水溶液は、-20°C で 3 か月間保存できます。
InChIKey:
JCBIVZZPXRZKTI-UHFFFAOYSA-N
EPAの化學(xué)物質(zhì)情報(bào):
Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1) (747-36-4)
安全性情報(bào)
  • リスクと安全性に関する聲明
  • 危険有害性情報(bào)のコード(GHS)
主な危険性  Xn,Xi
Rフレーズ  42/43-36/37/38-36-22
Sフレーズ  37/39-26
WGK Germany  3
RTECS 番號 KK3342500
HSコード  29334990
絵表示(GHS) GHS hazard pictograms
注意喚起語 警告
危険有害性情報(bào)
コード 危険有害性情報(bào) 危険有害性クラス 區(qū)分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 強(qiáng)い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
注意書き
P305+P351+P338 眼に入った場合:水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ヒドロキシクロロキン硫酸塩 価格 もっと(21)

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時(shí)間 購入
富士フイルム和光純薬株式會(huì)社(wako) W01TOC5648
Hydroxychloroquine sulfate
747-36-4 10mg ¥34000 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01TOC5648
Hydroxychloroquine sulfate
747-36-4 50mg ¥144000 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01MAS076061
2-((4-((7-Chloroquinolin-4-yl)amino)-pentyl)(ethyl)amino)ethanol sulfate
747-36-4 1g ¥42800 2024-03-01 購入
東京化成工業(yè) H1306 ヒドロキシクロロキン硫酸塩 >98.0%(HPLC)(N)
Hydroxychloroquine Sulfate >98.0%(HPLC)(N)
747-36-4 5g ¥8200 2024-03-01 購入
東京化成工業(yè) H1306 ヒドロキシクロロキン硫酸塩 >98.0%(HPLC)(N)
Hydroxychloroquine Sulfate >98.0%(HPLC)(N)
747-36-4 25g ¥27400 2024-03-01 購入

ヒドロキシクロロキン硫酸塩 MSDS


Hydroxychloroquine sulfate

ヒドロキシクロロキン硫酸塩 化學(xué)特性,用途語,生産方法

外観

白色~うすい黃色粉末~結(jié)晶

効能

抗マラリア薬

商品名

プラケニル (サノフィ)

説明

Hydroxychloroquine sulfate (also known as hydroxychloroquine) is an antimalarial medicine approved in the United States for either prevention or treatment of certain types of malaria, lupus erythematosus, and rheumatoid arthritis. It is sold under the brand name Plaquenil and it is also sold as a generic medicine. It is available in tablets of 155mg base (200mg salt).
説明図
Hydroxychloroquine sulfate has not been approved for the treatment of COVID-19. It has been used experimentally to treat certain people with COVID-19, including hospitalized patients. Hydroxychloroquine sulfate is being used to try and stop the COVID-19 virus from spreading inside your body. This may help you to get better.
Hydroxychloroquine sulfate is experimental because we do not know if it works for COVID-19. It is not approved by FDA for the treatment of COVID-19, but emergency use has been authorized for adults and adolescents who weigh 50 kg (110 pounds) or more and are hospitalized with COVID-19 if a clinical trial is not available or you are not able to participate in a clinical trial. There is limited information known about the safety and effectiveness (whether this will make you better) of using hydroxychloroquine sulfate for hospitalized patients with COVID-19.

化學(xué)的特性

White Cyrstalline Solid

使用

Hydroxychloroquine Sulfate can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

一般的な説明

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

薬理學(xué)

Antimalarial action: Hydroxychloroquine binds to DNA, interfering with protein synthesis. It also inhibits DNA and RNA polymerases. It’s active against asexual erythrocytic forms of Plasmodium malariae, P. ovale, P. vivax, and many strains of P. falciparum.
Amebicidal action: Mechanism of action is unknown.
Anti-inflammatory action: Mechanism of action is unknown. Drug may antagonize histamine and serotonin and inhibit prostaglandin effects by inhibiting conversion of arachidonic acid to prostaglandin F2; it may also inhibit chemotaxis of polymorphonuclear leukocytes, macrophages, and eosinophils.

薬物動(dòng)態(tài)學(xué)

Absorption: Absorbed readily and almost completely.
Distribution: Bound to plasma proteins. It’s concentrated in the liver, spleen, kidneys, heart, and brain and is strongly bound in melanin-containing cells.
Metabolism: Metabolized by the liver to desethylchloroquine and desethyl hydroxychloroquine.
Excretion: Most of an administered dose is excreted unchanged in urine. Drug and its metabolites are excreted slowly in urine; unabsorbed drug is excreted in feces. Small amounts of drug may be present in urine for months after it’s discontinued. Drug appears in breast milk.

臨床応用

Hydroxychloroquine sulfate is highly water soluble and exists in two different forms of different melting points. It is readily absorbed on oral administration, reaching peak plasma levels within 1 to 3 hours. It concentrates in organs such as the liver, spleen, kidneys, heart, lung, and brain, thereby prolonging elimination. Hydroxychloroquine is metabolized by N-dealkylation of the tertiary amines, followed by oxidative deamination of the resulting primary amine to the carboxylic acid derivative. In addition to possessing corneal and renal toxicity, hydroxychloroquine also may cause CNS, neuromuscular, GI, and hematological side effects. Hydroxychloroquine sulfate is indicated for the treatment of rheumatoid arthritis, lupus erythematosus, and malaria.

副作用

In addition to possessing corneal and renal toxicity, hydroxychloroquine also may cause CNS, neuromuscular, GI, and hematological side effects. Hydroxychloroquine sulfate is indicated for the treatment of rheumatoid arthritis, lupus erythematosus, and malaria

過量投與

Symptoms of drug overdose may appear within 30 minutes after ingestion and may include headache, drowsiness, visual changes, CV collapse, and seizures followed by respiratory and cardiac arrest.
Treatment is symptomatic. Empty stomach by emesis or lavage. After lavage, activated charcoal in an amount at least five times the estimated amount of drug ingested may be helpful if given within 30 minutes of ingestion.
Ultra-short-acting barbiturates may help control seizures. Intubation may become necessary. Peritoneal dialysis and exchange transfusions may also be useful. Forced fluids and acidification of the urine are helpful after the acute phase.

薬物相互作用

Anti-arrhythmics: increased risk of ventricular arrhythmias when hydroxychloroquine administered with amiodarone – avoid concomitant use
Digoxin: Hydroxychloroquine sulfate has been reported to increase plasma digoxin levels: serum digoxin levels should be closely monitored in patients receiving concomitant therapy.
Antibacterials: increased risk of ventricular arrhythmias when hydroxychloroquine administered with moxifloxacin – avoid concomitant use.
Ciclosporin: hydroxychloroquine increases plasma concentration of ciclosporin (increased risk of toxicity) .
Antacids: as with chloroquine, antacids may reduce absorption of hydroxychloroquine so it is advised that a 4 hour interval be observed between hydroxychloroquine and antacid dosaging.
Antidiabetic medicines: As hydroxychloroquine may enhance the effects of hypoglycaemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required.
Tamoxifen: may enhance the adverse/toxic effect of Hydroxychloroquine. Specifically, concomitant use of tamoxifen and hydroxychloroquine may increase the risk of retinal toxicity.

ヒドロキシクロロキン硫酸塩 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品


ヒドロキシクロロキン硫酸塩 生産企業(yè)

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ヒドロキシクロロキン硫酸塩  スペクトルデータ(1HNMR)


747-36-4(ヒドロキシクロロキン硫酸塩)キーワード:


  • 747-36-4
  • 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)ethanolsulfate(1:1)(
  • 2-((4-((7-Chloro-4-quinolinyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt)
  • Ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)-, sulfate (1:1) (salt)
  • Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-, sulfate (1:1) (salt)
  • Plaquinol
  • Hydroxychloroquine sulfate,98%
  • Hydroxychloroquin
  • Hydroxychloroquine Sulfate (200 mg)
  • Hydroxychloroquine sulfate, 98% 25GR
  • 2-[[4-[(7-Chloro-4-quinolinyl)aMino]pentyl]ethylaMino]ethanol
  • Hydroxychloroquine Sulfate API
  • 7-Chloro-4-[4-[N-ethyl-N-(2-hydroxyethyl)amino]-1-methylbutylamino]quinoline Sulfate N4-(7-Chloro-4-quinolyl)-N1-ethyl-N1-(2-hydroxyethyl)-1,4-pentanediamine Sulfate
  • 2-((4-((7-Chloroquinolin-4-yl)aMino)pentyl)(ethyl)aMino)ethanol sulfate
  • HYDROXYCHILOROQUINE SULPHATE
  • Hydroxychlorquine sulfate
  • Hydroxychloroquine Sulphate Imp.1
  • 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)-ethanosulfate(1:1)
  • 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-ethanosulfate(1:1)
  • plaquenilsulfate
  • 7-CHLORO-4-[4-[ETHYL-(2-HYDROXYETHYL)AMINO]-1-METHYLBUTYLAMINO]QUINOLINE
  • (+/-)-2-[[4-[(7-CHLORO-4-QUINOLINYL)AMINO]PENTYL]ETHYLAMINO]ETHANOL SULFATE
  • HYDROXYCHLOROQUINE SULFATE
  • Ercoquin, Plaquenil Sulfate, Quensyl
  • HYDROXYCHLOROQUINESULPATE
  • HYDROXYCHLOROQUINESULFATE,USP
  • 7-Chloro-4-[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutylamino]-quinoline Sulfate
  • Ercoquin
  • Quensyl
  • HCQ sulfate
  • Hydroxychloroquene Sulphate
  • 2-[[4-[(7-クロロキノリン-4-イル)アミノ]ペンチル]エチルアミノ]エタノール·硫酸塩
  • ヒドロキシクロロキン硫酸塩
  • 硫酸ヒドロキシクロロキン
  • 7-クロロ-4-[4-[N-エチル-N-(2-ヒドロキシエチル)アミノ]-1-メチルブチルアミノ]キノリン硫酸塩
  • N4-(7-クロロ-4-キノリル)-N1-エチル-N1-(2-ヒドロキシエチル)-1,4-ペンタンジアミン硫酸塩
  • ヒドロキシクロロキン 硫酸
  • ヒドロキシクロロキン硫酸塩 (JAN)
  • 2-[[4-[(7-クロロキノリン-4-イル)アミノ]ペンチル]エチルアミノ]エタノール?硫酸塩
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