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PCNA-I1

 化學(xué)構(gòu)造式
444930-42-1
CAS番號.
444930-42-1
化學(xué)名:
別名:
英語名:
PCNA-I1
英語別名:
PCNA-I1, 10 mM in DMSO;PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide;2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide;N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
CBNumber:
CB33067568
化學(xué)式:
C17H14N2O2S
分子量:
310.37
MOL File:
444930-42-1.mol

PCNA-I1 物理性質(zhì)

比重(密度) :
1.30±0.1 g/cm3(Predicted)
貯蔵溫度 :
Store at -20°C
溶解性:
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
外見 :
A crystalline solid
酸解離定數(shù)(Pka):
8.31±0.50(Predicted)
色:
Light yellow to yellow

安全性情報

PCNA-I1 価格

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入

PCNA-I1 化學(xué)特性,用途語,生産方法

説明

PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 μM) over non-transformed cells (IC50s = 0.99-2 μM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.

PCNA-I1 上流と下流の製品情報

原材料

準(zhǔn)備製品


PCNA-I1 生産企業(yè)

Global( 50)Suppliers
名前 電話番號 電子メール 國籍 製品カタログ 優(yōu)位度
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
+86-18341751992 +86-15382112998
757984502@qq.com China 892 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
orders@jknbiochem.com China 5221 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921
sales@pharmacodia.com China 2317 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9805 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
klq@cw-bio.com China 5960 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
2853530910@QQ.com China 8011 62

  スペクトルデータ(1HNMR)



  • 444930-42-1
  • N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
  • 2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
  • PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1
  • N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide
  • PCNA-I1, 10 mM in DMSO
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