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MK-4827 (tosylate) synthesis
- Product Name:MK-4827 (tosylate)
- CAS Number:1038915-73-9
- Molecular formula:C26H28N4O4S
- Molecular Weight:492.5899
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1038915-60-4
288 suppliers
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104-15-4
737 suppliers
$133.00/500g
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1038915-73-9
132 suppliers
$29.00/1mg
Yield:1038915-73-9 110 g
Reaction Conditions:
in water at 20 - 30; for 4 h;Inert atmosphere;
Steps:
3 Method for synthesizing 2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-carboxamide p-toluenesulfonic acid salt salt crystal form A
100 g of 2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-formyl was added to the reaction flask. 750mL of ethanol,Water 250mL temperature control to 20 ° C - 30 ° C,Slowly add 50% (mass fraction) of p-toluenesulfonic acid (75g) monohydrate under nitrogen protection Solution,After the addition, the mixture was stirred at a temperature of 20 ° C for 4 hours, filtered and washed with water, and dried under vacuum at 40 ° C to obtain crystal form A 110 g.
References:
Guangzhou Keruite Biological Technology Co., Ltd.;Wang Yong;Yu Jinquan CN108530425, 2018, A Location in patent:Paragraph 0062-0064
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1476776-84-7
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104-15-4
737 suppliers
$133.00/500g

1038915-73-9
132 suppliers
$29.00/1mg
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1038915-60-4
288 suppliers
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6192-52-5
567 suppliers
$1.70/25kg-r
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1038915-73-9
132 suppliers
$29.00/1mg
![tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate](/CAS/20180703/GIF/1038916-11-8.gif)
1038916-11-8
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104-15-4
737 suppliers
$133.00/500g
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1038915-73-9
132 suppliers
$29.00/1mg
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5471-82-9
209 suppliers
$10.00/5g
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1038915-73-9
132 suppliers
$29.00/1mg