ソマトトロピン 化學(xué)特性,用途語,生産方法
外観
凍結(jié)乾燥品
定義
本品は、大腸菌 E.coli によって産生させた単鎖の遺伝子組換ヒトペプチドである。出発遺伝子は、上皮成長ホルモンのコードを持つヒト細胞から直接単離されたものである。上皮成長ホルモンは、ジスルフィド結(jié)合と糖鎖付加の両方またはいずれか一方を含む最大で217個のアミノ酸からなり、固有のアミノ酸配列を持つ。
溶解性
本品1mg+水1mgで全容水に溶ける。
解説
ソマトトロピンは，脳下垂體前葉から分泌されるホルモンで、分子量約2萬2000のペプチド。成長促進作用?たんぱく質(zhì)同化促進作用などがある。成長ホルモン。小學(xué)館 デジタル大辭泉について 情報 | 凡例
用途
ヒト成長ホルモン (hGH、別
名ソマトロピン ) は 191 のアミノ酸殘基、分
子量約 22kDa からなるポリペプチドです。
成長促進作用、糖新生促進作用を示します。
用途
生理作用の研究。
化粧品の成分用途
保水剤、表面改質(zhì)剤、皮膚コンディショニング剤、皮膚保護剤
説明
Somatotropin, a second-generation (methionine-free) human growth hormone
produced by recombinant technology, was launched in the U.S.A. for the treatment
of growth failure in children due to chronic renal insufficiency before transplantation
and for the long term treatment of short stature in children with growth failure due to a
lack of endogenous growth hormone secretion. The efficacy of somatotropin is
reportedly comparable to the first biosynthetic growth hormone somatrem, which
contains a methionyl residue, but with less frequent antibody formation and rarely
causes allergic effects or impairs growth response. Somatotropin is also in clinical
trials for the treatment of growth hormone deficiency in adults and is currently under
approval review for Turner's syndrome.
化學(xué)的特性
White or almost white powder.
世界保健機関（WHO）
Somatropin, a pituitary-derived human growth hormone, has been
used in the treatment of hypopituitary dwarfism for over twenty years. In 1985 it
became known that Creutzfeldt-Jakob disease, a potentially fatal form of brain
degeneration resulting from a slow neurotropic viral infection, had developed in
several patients who had received preparations of somatropin in the late
1960s/early 1970s. This led to the withdrawal of these preparations in many
countries. An international collaborative effort was maintained to identify newlydiagnosed
cases. By 1990 a total of 30 such cases had been notified. More efficient
purification procedures introduced during the 1970s greatly reduced the risk of
viral contamination, but products containing pituitary-derived somatropin have
been superseded by biosynthetically-manufactured preparations produced using
recombinant techniques.
一般的な説明
Somatropin for injection(Humatrope) is a natural-sequence human GH of rDNAorigin. Its composition and sequence of amino acids areidentical with those of human GH of pituitary origin. It isadministered intramuscularly or subcutaneously. Thedosage range is 0.05 to 0.1 IU.
臨床応用
Human Growth Hormone (Somatotropin) is a protein that is essential for normal growth and developmentin humans. Human Growth Hormone(hGH) affects many aspects of humandevelopment and metabolism including longitudinalgrowth, regulation (increase) of protein synthesis and lipolysis,and regulation (decrease) of glucose metabolism. Human Growth Hormone(hGH)has been used as a drug since the 1950s, and it has been extremelysuccessful in the treatment of classic growth hormonedeficiency, chronic renal insufficiency, Turner syndrome,failure to lactate in women, and Prader-Willisyndrome. In its long history, the hormone has been remarkablysuccessful and free of side effects.
副作用
Carpal tunnel syndrome.
Increased insulin resistance.
Type 2 diabetes.
Swelling in the arms and legs (edema).
Joint and muscle pain.
For men, enlargement of breast tissue (gynecomastia).
Increased risk of certain cancers.
ソマトトロピン 上流と下流の製品情報
原材料
準備製品