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ChemicalBook >> CAS DataBase List >>Sorbic acid

Sorbic acid

CAS No.
22500-92-1
Chemical Name:
Sorbic acid
Synonyms
CBNumber:
CB9954577
Molecular Formula:
C6H8O2
Molecular Weight:
0
MDL Number:
MFCD00002703
MOL File:
22500-92-1.mol
MSDS File:
SDS
Last updated:2023-08-15 11:08:22

Sorbic acid Properties

solubility Slightly soluble in water, freely soluble in ethanol (96 per cent).
Odor characteristic
InChI InChI=1S/C6H8O2/c1-2-3-4-5-6(7)8/h2-5H,1H3,(H,7,8)/b3-2+,5-4+
InChIKey WSWCOQWTEOXDQX-MQQKCMAXSA-N
SMILES C(O)(=O)/C=C/C=C/C
LogP 1.268 (est)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Sorbic acid Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Chemical Properties

Sorbic acid is a tasteless, white to yellow-white crystalline powder with a faint characteristic odor.

Uses

Pharmaceutic aid (antimicrobial agent).

Definition

ChEBI: A hexadienoic acid with double bonds at C-2 and C-4; it has four geometrical isomers, of which the trans,trans-form is naturally occurring.

Production Methods

Naturally occurring sorbic acid may be extracted as the lactone (parasorbic acid) from the berries of the mountain ash Sorbus aucuparia L. (Fam. Rosaceae). Synthetically, sorbic acid may be prepared by the condensation of crotonaldehyde and ketene in the presence of boron trifluoride; by the condensation of crotonaldehyde and malonic acid in pyridine solution; or from 1,1,3,5- tetraalkoxyhexane. Fermentation of sorbaldehyde or sorbitol with bacteria in a culture medium has also been used.

Pharmaceutical Applications

Sorbic acid is an antimicrobial preservative with antibacterial and antifungal properties used in pharmaceuticals, foods, enteral preparations, and cosmetics. Generally, it is used at concentrations of 0.05–0.2% in oral and topical pharmaceutical formulations, especially those containing nonionic surfactants. Sorbic acid is also used with proteins, enzymes, gelatin, and vegetable gums. It has been shown to be an effective preservative for promethazine hydrochloride solutions in a concentration of 1 g/L.
Sorbic acid has limited stability and activity against bacteria and is thus frequently used in combination with other antimicrobial preservatives or glycols, when synergistic effects appear to occur.

Safety

Sorbic acid is used as an antimicrobial preservative in oral and topical pharmaceutical formulations and is generally regarded as a nontoxic material. However, adverse reactions to sorbic acid and potassium sorbate, including irritant skin reactions and allergic hypersensitivity skin reactions (which are less frequent), have been reported.
Other adverse reactions that have been reported include exfoliative dermatitis due to ointments that contain sorbic acid, and allergic conjunctivitis caused by contact lens solutions preserved with sorbic acid.
No adverse reactions have been described after systemic administration of sorbic acid, and it has been reported that it can be ingested safely by patients who are allergic to sorbic acid. However, perioral contact urticaria has been reported.
The WHO has set an estimated total acceptable daily intake for sorbic acid, calcium sorbate, potassium sorbate, and sodium sorbate, expressed as sorbic acid, at up to 25 mg/kg bodyweight. Animal toxicological studies have shown no mammalian carcinogenicity or teratogenicity for sorbic acid consumed at up to 10% of the diet.
LD50 (mouse, IP): 2.82 g/kg
LD50 (mouse, oral): 3.20 g/kg
LD50 (mouse, SC): 2.82 g/kg
LD50 (rat, oral): 7.36 g/kg

storage

Sorbic acid is sensitive to oxidation, particularly in the presence of light; oxidation occurs more readily in aqueous solution than in the solid form. Sorbic acid may be stabilized by phenolic antioxidants such as 0.02% propyl gallate.
Sorbic acid is combustible when exposed to heat or flame. When heated to decomposition, it emits acrid smoke and irritating fumes. The bulk material should be stored in a well-closed container, protected from light, at a temperature not exceeding 40℃.

Incompatibilities

Sorbic acid is incompatible with bases, oxidizing agents, and reducing agents. Some loss of antimicrobial activity occurs in the presence of nonionic surfactants and plastics. Oxidation is catalyzed by heavy-metal salts. Sorbic acid will also react with sulfur-containing amino acids, although this can be prevented by the addition of ascorbic acid, propyl gallate, or butylhydroxytoluene.
When stored in glass containers, the solution becomes very pH sensitive; therefore, preparations using sorbic acid as a preservative should be tested for their microbial purity after prolonged periods of storage.
Aqueous solutions of sorbic acid without the addition of antioxidants are rapidly decomposed when stored in polypropylene, polyvinylchloride, and polyethylene containers.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (ophthalmic solutions; oral capsules, solutions, syrups, tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sorbic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 23325 58
Chongqing Chuandong Chemical (Group) Co. Ltd.
+86-13637972665 +86-13637972665 wxc@cd1958.com China 81 58
Beijing Ouhe Technology Co., Ltd 010-82967028 13552068683 2355560935@qq.com China 12438 60
shanghai science Bio-Pharmceutical.co,ltd. 021-021-57872719 13761402923 245662540@qq.com China 309 60
Nanjing chemical reagent co. LTD 025-025-58369808 17895012682 1848231502@qq.com China 3501 58
Hubei Xinhe Chemical Industry Co.,ltd. 027-83258456 15392830626 linkworld02@163.com China 206 58
Zhengzhou Yuhe Food Additive Co. LTD 0371-56060979 13838386843 2922109373@qq.com China 507 58
Shandong Aicai Biotechnology Co. , Ltd. 135-37016375 13573016375 3358761976@qq.com China 511 58
Nantong Zhonghe Chemical New Materials Co., Ltd 13003551299 13003551299 2369399482@qq.com China 7566 58
Xi'an Jinxiang Pharmaceutical Accessories Co., Ltd. 029-19991803015 19991803015 1309520151@qq.com China 235 58

View Lastest Price from Sorbic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sorbic acid USP/EP/BP pictures 2021-07-23 Sorbic acid USP/EP/BP
22500-92-1
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
22500-92-1