ChemicalBook >> CAS DataBase List >>BMS-763534
BMS-763534
- CAS No.
- 1188407-40-0
- Chemical Name:
- BMS-763534
- Synonyms
- BMS-763534;BMS-763534 >=98% (HPLC);2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-
- CBNumber:
- CB94669866
- Molecular Formula:
- C18H21ClF2N4O3
- Molecular Weight:
- 414.83
- MDL Number:
- MFCD30718578
- MOL File:
- 1188407-40-0.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Melting point | 103.4-104.4 °C(Solv: heptane (142-82-5)) |
|---|---|
| Boiling point | 470.4±55.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: 25mg/mL, clear |
| pka | 1.89±0.40(Predicted) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -40 to -55°, c = 0.8 in chloroform-d |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
BMS-763534 price More Price(2)
BMS-763534 Chemical Properties,Uses,Production
Biochem/physiol Actions
BMS-763534 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 = 0.26 & 0.4 nM against 150 pM ovine CRF for binding rat & human CRF-R1, respectively), potency (IC50 = 1.0 nM against 0.3 nM CRF-stimulated ATCH secretion from primary rat anterior pituitary cells), and selectivity, displaying little affinity toward porcine CRF-R2/CRF2 and 46 other receptor/channel/transporter proteins (IC50 >10 μM). BMS-763534 inhibits CRF-stimulated cAMP production in human Y-79 retinoblastoma cells in cultures (pA2 = 9.47) and exhibits anxiolytic efficacy in a rat situational anxiety model in vivo (0.5-3 mg/kg p.o.).
BMS-763534 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-763534 Suppliers
Global( 4)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44807 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Sigma-Aldrich | 80 |
| Energy Chemical | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from BMS-763534 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | BMS-763534
1188407-40-0
|
US $3400.00-2580.00 / mg | 10g | TargetMol Chemicals Inc. |
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- BMS-763534
1188407-40-0
- US $3400.00-2580.00 / mg
- TargetMol Chemicals Inc.
BMS-763534
BMS-763534 >=98% (HPLC)
2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-
1188407-40-0