Synthesis

Chem-Matrix? Wang resin (0.6g, 0.6 mmol/g loading) was swelled in an anhydrous CH2Cl2 (20 mL) for an hour. Tricholoracetonitrile (5.4 mmol, 0.54 mL) was added to resin and the mixture was cooled to 0 °C. A catalytic amount of DBU was added to the suspension over 5 min and the reaction continued at 0 °C for an additional 45 min. The color of the solution changed from clear to light brown. The resin was washed with CH2Cl2 (4 x 20 mL), DMSO (2 x 20 mL), THF (3 x 20 mL) and CH2Cl2 (3 x 20 mL). FTIR (KBr, cm-1 ) 3055, 2872, 1665, 1512, 1452, 1348, 1265, 1093, 951, 836, 798, 730, 700, 648.