Moxonidine (hydrochloride)
- CAS No.
- 75536-04-8
- Chemical Name:
- Moxonidine (hydrochloride)
- Synonyms
- BDF5895 hydrochloride;Moxonidine HCl - Bio-X ?;Moxonidine hydrochloride CP;MOXONIDINE HYDROCHLORIDE CP; MOXONIDINE HCL; BDF-5895 HCL;Moxonidine hydrochloride, I1 Imidazoline receptor and alpha2 adrenergic agonist
- CBNumber:
- CB92685930
- Molecular Formula:
- C9H13Cl2N5O
- Molecular Weight:
- 278.14
- MDL Number:
- MFCD00865794
- MOL File:
- 75536-04-8.mol
Moxonidine (hydrochloride) price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | H810 | MoxonidineHCl | 75536-04-8 | 5mg | $19 | 2021-12-16 | Buy |
| AK Scientific | H810 | MoxonidineHCl | 75536-04-8 | 25mg | $30 | 2021-12-16 | Buy |
| AK Scientific | H810 | MoxonidineHCl | 75536-04-8 | 100mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BM164613 | Moxonidine hydrochloride | 75536-04-8 | 10mg | $72 | 2021-12-16 | Buy |
| AK Scientific | H810 | MoxonidineHCl | 75536-04-8 | 500mg | $175 | 2021-12-16 | Buy |
Moxonidine (hydrochloride) Chemical Properties,Uses,Production
Uses
Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. Target: I1-R Moxonidine Hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Moxonidine reduced stimulated NE overflow (log EC50: -6.15 +/- 0.14). AGN192403, a selective ligand at I1-R, had no influence on the dose-response curve of moxonidine (log EC50: -6.01 +/- 0.25) [1]. The hypotensive and bradycardic actions of moxonidine but not clonidine are mediated through imidazoline receptors and are dependent on intact noradrenergic pathways within the RVLM. Furthermore, the noradrenergic innervation may be associated with a 42 kDa imidazoline receptor protein [2].
References
[1] Schafer, U., et al., Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. J Pharmacol Exp Ther, 2002. 303(3): p. 1163-70. DOI:10.1124/jpet.102.041657
[2] Chan, C.K., et al., Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience, 2005. 132(4): p. 991-1007. DOI:10.1016/j.neuroscience.2005.01.032
Moxonidine (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Moxonidine (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
| Aikon International Limited | 025-66113011 13155353615 | qzhang@aikonchem.com | China | 15394 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| Supplier | Advantage |
|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
| MedChemexpress LLC | 58 |
| LETOPHARM LIMITED | 58 |
| SPIRO PHARMA | 55 |
| Musechem | 60 |
| Aikon International Limited | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 58 |
| DC Chemicals | 58 |