WAY 181187
- CAS No.
- 554403-49-5
- Chemical Name:
- WAY 181187
- Synonyms
- SAX-187;WAY 181187;WAY181187 HCl;WAY-181187(SAX-187);WAY 181187|||WAY181187;SAX-187, 10 mM in DMSO;WAY181187 hydrochloride;WAY181187.HCl(WAY-181,187);SAX-187;WAY 181187;WAY-181187(SAX-187);WAY181187 HYDROCHLORIDE;1H-Indole-3-ethanamine, 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-
- CBNumber:
- CB92628524
- Molecular Formula:
- C15H13ClN4O2S2
- Molecular Weight:
- 380.87
- MDL Number:
- MFCD09833239
- MOL File:
- 554403-49-5.mol
- MSDS File:
- SDS
| Density | 1.67±0.1 g/cm3(Predicted) |
|---|---|
| pka | 9.30±0.10(Predicted) |
| form | Solid |
| color | White to yellow |
| FDA UNII | WXE3H7W295 |
WAY 181187 Chemical Properties,Uses,Production
Uses
WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].
in vivo
Acute administration of WAY-181187 (3-30 mg/kg, s.c.) significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 (30 mg/kg, s.c.) produces modest yet significant decreases in cortical dopamine and 5-HT levels[1].
| Animal Model: | Adult male Sprague-Dawley rats weighing 280–350 g[1] |
| Dosage: | 3, 10, or 30 mg/kg |
| Administration: | Acute dministered by s.c. |
| Result: | Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine. |
IC 50
5-HT6 Receptor: 2.2 nM (Ki); 5-HT6 Receptor: 6.6 nM (EC50)
References
[1] Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. DOI:10.1038/sj.npp.1301503
[2] Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. DOI:10.1016/j.ejphar.2011.04.028
WAY 181187 Preparation Products And Raw materials
Raw materials
Preparation Products
WAY 181187 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38642 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
