Isoalantolactone
- CAS No.
- 470-17-7
- Chemical Name:
- Isoalantolactone
- Synonyms
- ISOHELENIN;ISOALANTOACTONE;isocoxiolactone;ISOALANTOLACTONE;(+)-Isoalantolactone;ISOALANTOLACTONE (RG);Isoalantolactone USP/EP/BP;(+)-Isoalantolactone|||Isohelenin;Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-;methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-
- CBNumber:
- CB9234785
- Molecular Formula:
- C15H20O2
- Molecular Weight:
- 232.32
- MDL Number:
- MFCD08689940
- MOL File:
- 470-17-7.mol
- MSDS File:
- SDS
| Melting point | 115℃ |
|---|---|
| Boiling point | 364.9±42.0 °C(Predicted) |
| Density | 1.07±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml) or ethanol (30 mg/ml) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| LogP | 3.420 |
| CAS DataBase Reference | 470-17-7(CAS DataBase Reference) |
| FDA UNII | BYH07P620U |
| NIST Chemistry Reference | Naphtho(2,3-b)furan-2(3h)-one, decahydro-8a-methyl-3,5-bis(methylene)-, (3ar-(3a«alpha»,4a«alpha»,8a«beta»,9a«alpha»))-(470-17-7) |
Isoalantolactone price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 300468 | Isoalantolactone | 470-17-7 | 20mg | $320 | 2021-12-16 | Buy |
| Usbiological | 280646 | Isoalantolactone | 470-17-7 | 50mg | $333 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI32778 | Isoalantolactone | 470-17-7 | 1g | $600 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0000494 | ISOALANTOLACTONE 95.00% | 470-17-7 | 1G | $837.09 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb594031 | Isoalantolactone | 470-17-7 | 100mg | $408 | 2021-12-16 | Buy |
Isoalantolactone Chemical Properties,Uses,Production
Description
Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 μM)1 acting via inhibition of IKK?6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6
Uses
Isoalantolactone is a sesquiterpene lactone used in the treatment of cancer. It can inhibit tumor cell growth and induce apoptosis.
Definition
ChEBI: A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.
References
Bork et al. (1997), Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NK-kappaB; FEBS Lett., 402 85 Mazor et al. (2000), Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium; Cytokine, 12 239 Wong and Menendez (1999), Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells; Biochem. Biophys. Res. Commun., 262 375 Li et al. (2001), Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NK-kappaB transcription factor; Int. J. Mol. Med., 7 527 Sheehan et al. (2002), Protective effects of isohelenin, an inhibitor of nuclear factor KappaB in endotoxic shock in rats; Endotoxin Res, 8 99 Xing et al. (2019), Isoalantolactone inhibits IKK? kinase activity to interrupt the NF-kB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma; Cancer Med., 8 1655
Isoalantolactone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Jiangsu Yongjian Pharmaceutical Co.,Ltd | +86-0523-80183620 +86-17701422015 | 982552664@qq.com | China | 258 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9218 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
View Lastest Price from Isoalantolactone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Isoalantolactone
470-17-7
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2023-02-24 | Isoalantolactone
470-17-7
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-13 | Isoalantolactone
470-17-7
|
US $110.00 / kg | 1kg | 99% | 100MT | Hebei baicao biology science and technology co., ltd |
-
- Isoalantolactone
470-17-7
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Isoalantolactone
470-17-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Isoalantolactone
470-17-7
- US $110.00 / kg
- 99%
- Hebei baicao biology science and technology co., ltd