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ChemicalBook >> CAS DataBase List >>Isoalantolactone

Isoalantolactone

CAS No.
470-17-7
Chemical Name:
Isoalantolactone
Synonyms
ISOHELENIN;ISOALANTOACTONE;isocoxiolactone;ISOALANTOLACTONE;(+)-Isoalantolactone;ISOALANTOLACTONE (RG);Isoalantolactone USP/EP/BP;(+)-Isoalantolactone|||Isohelenin;Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-;methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-
CBNumber:
CB9234785
Molecular Formula:
C15H20O2
Molecular Weight:
232.32
MDL Number:
MFCD08689940
MOL File:
470-17-7.mol
MSDS File:
SDS
Last updated:2023-08-25 11:46:16

Isoalantolactone Properties

Melting point 115℃
Boiling point 364.9±42.0 °C(Predicted)
Density 1.07±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 50 mg/ml) or ethanol (30 mg/ml)
form solid
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
LogP 3.420
CAS DataBase Reference 470-17-7(CAS DataBase Reference)
FDA UNII BYH07P620U
NIST Chemistry Reference Naphtho(2,3-b)furan-2(3h)-one, decahydro-8a-methyl-3,5-bis(methylene)-, (3ar-(3a«alpha»,4a«alpha»,8a«beta»,9a«alpha»))-(470-17-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard Codes  Xn
Risk Statements  40
Safety Statements  22-36
HS Code  29322090

Isoalantolactone price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 300468 Isoalantolactone 470-17-7 20mg $320 2021-12-16 Buy
Usbiological 280646 Isoalantolactone 470-17-7 50mg $333 2021-12-16 Buy
Biosynth Carbosynth FI32778 Isoalantolactone 470-17-7 1g $600 2021-12-16 Buy
American Custom Chemicals Corporation CCH0000494 ISOALANTOLACTONE 95.00% 470-17-7 1G $837.09 2021-12-16 Buy
Biorbyt Ltd orb594031 Isoalantolactone 470-17-7 100mg $408 2021-12-16 Buy
Product number Packaging Price Buy
300468 20mg $320 Buy
280646 50mg $333 Buy
FI32778 1g $600 Buy
CCH0000494 1G $837.09 Buy
orb594031 100mg $408 Buy

Isoalantolactone Chemical Properties,Uses,Production

Description

Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 μM)1 acting via inhibition of IKK?6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6

Uses

Isoalantolactone is a sesquiterpene lactone used in the treatment of cancer. It can inhibit tumor cell growth and induce apoptosis.

Definition

ChEBI: A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.

References

Bork et al. (1997), Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NK-kappaB; FEBS Lett., 402 85 Mazor et al. (2000), Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium; Cytokine, 12 239 Wong and Menendez (1999), Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells; Biochem. Biophys. Res. Commun., 262 375 Li et al. (2001), Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NK-kappaB transcription factor; Int. J. Mol. Med., 7 527 Sheehan et al. (2002), Protective effects of isohelenin, an inhibitor of nuclear factor KappaB in endotoxic shock in rats; Endotoxin Res, 8 99 Xing et al. (2019), Isoalantolactone inhibits IKK? kinase activity to interrupt the NF-kB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma; Cancer Med., 8 1655

69993-39-1
470-17-7
Synthesis of Isoalantolactone from Naphtho[2,3-b]furan-2(3H)-one, decahydro-8a-methyl-5-methylene-3-[(phenylthio)methylene]-, [3aR-(3E,3aα,4aα,8aβ,9aα)]- (9CI)
Global( 224)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Jiangsu Yongjian Pharmaceutical Co.,Ltd
+86-0523-80183620 +86-17701422015 982552664@qq.com China 258 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907 qinhe02@xaltbio.com China 997 58
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9218 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3619 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Shanghai Standard Technology Co., Ltd.
18502101150 ft-sales@nature-standard.com CHINA 1923 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58

View Lastest Price from Isoalantolactone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Isoalantolactone pictures 2024-04-12 Isoalantolactone
470-17-7
US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
Isoalantolactone pictures 2023-02-24 Isoalantolactone
470-17-7
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
Isoalantolactone pictures 2023-02-13 Isoalantolactone
470-17-7
US $110.00 / kg 1kg 99% 100MT Hebei baicao biology science and technology co., ltd
  • Isoalantolactone pictures
  • Isoalantolactone
    470-17-7
  • US $0.00 / mg
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.
  • Isoalantolactone pictures
  • Isoalantolactone
    470-17-7
  • US $110.00 / kg
  • 99%
  • Hebei baicao biology science and technology co., ltd
11(13)-dien-12-oicacid,8-beta-hydroxy-eudesma-4(14gamma-lactone ISOALANTOACTONE ISOALANTOLACTONE ISOHELENIN (3ar,4as,8ar,9ar)-8a-methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)- Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a- (3aR)-3aα,4,4aα,5,6,7,8,8a,9,9aα-Decahydro-3,5-bismethylene-8aβ-methylnaphtho[2,3-b]furan-2(3H)-one (3aR,4aα,9aα)-3a,4,4a,5,6,7,8,8a,9,9a-Decahydro-8aβ-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2(3H)-one ISOALANTOLACTONE (RG) Isoalantolactone (3aR,4aS,8aR,9aR)-8a-Methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one (3AR,4aS,8aR,9aR)-8a-methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one Isoalantolactone, 98%, from Inula helenium L. Naphtho[2,3-b]furan-2(3H)-one, decahydro-8a-methyl-3,5-bis(methylene)-, (3aR,4aS,8aR,9aR)- Isoalantolactone USP/EP/BP (+)-Isoalantolactone isocoxiolactone (+)-Isoalantolactone|||Isohelenin 470-17-7 Inhibitors Miscellaneous Natural Products chiral chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract