Benzeneacetamide, α-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-, (αR)-
- CAS No.
- 2377238-62-3
- Chemical Name:
- Benzeneacetamide, α-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-, (αR)-
- Synonyms
- Netarsudil Impurity 13;Benzeneacetamide, α-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-, (αR)-
- CBNumber:
- CB89274619
- Molecular Formula:
- C19H19N3O2
- Molecular Weight:
- 321.37
- MDL Number:
- MOL File:
- 2377238-62-3.mol
Benzeneacetamide, α-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-, (αR)- Chemical Properties,Uses,Production
Uses
(R)-AR-13503 ((R)-AR-13324 M1 metabolite) is the the (R)-enantiomer of AR-13503 (HY-12798C). AR-13503 is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research[1][2][3].
References
[1] Ding J, et al. ROCK/PKC inhibitor AR-13503 inhibits angiogenesis and protects the barrier function of retinal pigment epithelium[J]. Investigative Ophthalmology & Visual Science, 2018, 59(9): 205-205.
[2] Carbajal K, et al. AR-13503 Enhances the efficacy of aflibercept in a mouse model of proliferative diabetic retinopathy[J]. Investigative Ophthalmology & Visual Science, 2018, 59(9): 200-200.
[3] Halasz E, et al. AR-13503, a ROCK inhibitor, reduces rod axon retraction during retinal detachment[J]. Investigative Ophthalmology & Visual Science, 2018, 59(9): 4221-4221.
Benzeneacetamide, α-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-, (αR)- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzeneacetamide, α-(aminomethyl)-4-(hydroxymethyl)-N-6-isoquinolinyl-, (αR)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TLC Pharmaceutical Standards Ltd. | 18012923235; 18012923235 | chinasales04@tlcstandards.com.cn | China | 7407 | 58 |
| Supplier | Advantage |
|---|---|
| TLC Pharmaceutical Standards Ltd. | 58 |