Hederagenin
- CAS No.
- 465-99-6
- Chemical Name:
- Hederagenin
- Synonyms
- Hederidin;NSC 24954;HEDERAGENIN;hederagenol;Hederogenin;Rangefinder;Hederagenine;MELANTHIGENIN;Vaccaric acid;Kalosapogenin
- CBNumber:
- CB8739586
- Molecular Formula:
- C30H48O4
- Molecular Weight:
- 472.71
- MDL Number:
- MFCD00017385
- MOL File:
- 465-99-6.mol
- MSDS File:
- SDS
| Melting point | 332-334° |
|---|---|
| alpha | D20 +81° (c = 0.7 in pyridine) |
| Boiling point | 493.44°C (rough estimate) |
| Density | 0.9871 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | methanol: soluble1mg/mL |
| pka | 4.63±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| λmax | 405nm(H2SO4)(lit.) |
| Merck | 14,4624 |
| InChIKey | PGOYMURMZNDHNS-MYPRUECHSA-N |
| LogP | 7.410 (est) |
| FDA UNII | RQF57J8212 |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-45-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29181990 | |||||||||
| NFPA 704 |
|
Hederagenin price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H3916 | Hederagenin ≥97% (HPLC) | 465-99-6 | 10mg | $477 | 2024-03-01 | Buy |
| TCI Chemical | H1645 | Hederagenin >98.0%(HPLC)(T) | 465-99-6 | 50mg | $164 | 2024-03-01 | Buy |
| TCI Chemical | H1645 | Hederagenin >98.0%(HPLC)(T) | 465-99-6 | 200mg | $565 | 2024-03-01 | Buy |
| Cayman Chemical | 27030 | Hederagenin | 465-99-6 | 250mg | $629 | 2024-03-01 | Buy |
| Cayman Chemical | 27030 | Hederagenin | 465-99-6 | 500mg | $1116 | 2024-03-01 | Buy |
Hederagenin Chemical Properties,Uses,Production
Description
Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
Chemical Properties
White Solid
Uses
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
Definition
ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).
in vivo
Hederagenin (25 mg/kg; po; 11 d) alone did not affect tumor growth in NCI-H1299 xenograft mice. However, it has a synergistic effect with Cisplatin (1 mg/kg) to inhibit tumor growth[4].
Hederagenin (50 mg/kg; po; once daily for 21 days) exerts anti-inflammatory and anti-apoptotic activities and reduces liver damage induced by 25% ethanol in mice[5].
Hederagenin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 1169 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 1287 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
View Lastest Price from Hederagenin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-09 | Hederagenin
465-99-6
|
US $80.00 / mg | 99.2% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Hederagenin
465-99-6
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-24 | Hederagenin
465-99-6
|
US $0.00 / mg | 5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Hederagenin
465-99-6
- US $80.00 / mg
- 99.2%
- TargetMol Chemicals Inc.
-
- Hederagenin
465-99-6
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Hederagenin
465-99-6
- US $0.00 / mg
- Analytical Standard
- Shanghai Standard Technology Co., Ltd.