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ChemicalBook >> CAS DataBase List >>TD-165

TD-165

CAS No.
2305936-56-3
Chemical Name:
TD-165
Synonyms
TD-165;(2S,4R)-1-((2S)-2-(11-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CBNumber:
CB87243608
Molecular Formula:
C46H59N7O8S
Molecular Weight:
870.07
MDL Number:
MFCD33029328
MOL File:
Mol file
Last updated:2024-07-02 08:55:37

TD-165 Properties

Boiling point 1096.3±65.0 °C(Predicted)
Density 1.292±0.06 g/cm3(Predicted)
solubility DMSO : 50 mg/mL (57.47 mM; Need ultrasonic)
form Solid
pka 10.75±0.40(Predicted)
color White to yellow

TD-165 Chemical Properties,Uses,Production

Biological Activity

TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1]. TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1].TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1].

References

[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654.

TD-165 Preparation Products And Raw materials

Raw materials

Preparation Products

TD-165 Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32080 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8011 62
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1388 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62163 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18478 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2561 58

TD-165 Spectrum

2305936-56-3(TD-165)Related Search:

TD-165 (2S,4R)-1-((2S)-2-(11-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2305936-56-3