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ChemicalBook >> CAS DataBase List >>CAY10749

CAY10749

CAS No.
2337386-47-5
Chemical Name:
CAY10749
Synonyms
CAY10749;PARP/PI3K-IN-1;PARP/PI3K IN 1,PARP/PI-3K-IN-1,PARP/PI3KIN1;4-(3-(2-(6-Amino-4-(trifluoromethyl)pyridin-3-yl)-4-morpholino-5678-tetrahydropyrido-[34-d]pyrimidine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one;4-[[3-[[2-[6-amino-4-(trifluoromethyl)-3-pyridinyl]-5,8-dihydro-4-(4-morpholinyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone
CBNumber:
CB86197920
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD34469871
MOL File:
Mol file
Last updated:2024-07-02 08:55:37

CAY10749 Properties

storage temp. Store at -20°C
solubility DMF: 11mg/mL,DMF:PBS (pH 7.2) (1:2): 0.3mg/mL,DMSO: 10mg/mL
form A crystalline solid
color White to off-white

CAY10749 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation HCH0116614 2-(3-(1-BENZOYLAMINO-2,2,2-TRICHLORO-ETHYL)-THIOUREIDO)-BENZOIC ACID METHYL ESTER 95.00% 2337386-47-5 5MG $499.95 2021-12-16 Buy
Product number Packaging Price Buy
HCH0116614 5MG $499.95 Buy

CAY10749 Chemical Properties,Uses,Production

Biological Activity

CAY10749 is a dual inhibitor of poly(ADP-ribose) polymerase (PARP) and PI3K (IC50s = 6.03, 3.63, 5.62, and 7.41 nM for PARP1, PARP2, PI3Kα, and PI3Kδ, respectively).1 It is selective for these enzymes over PI3Kβ and PI3Kγ (IC50s = 288.4 and 831.76 nM, respectively), as well as a panel of 374 additional kinases at 1 μM. CAY10749 (1 μM) induces dsDNA break formation in a neutral comet assay and apoptosis in MDA-MB-468 breast cancer cells. It inhibits proliferation of eight cancer cell lines, including pancreatic, ovarian, lymphoma, leukemia, and lung cancer cells, with IC50 values ranging from 398.11 to 2,818.38 nM. CAY10749 (50 mg/kg twice per day) reduces tumor growth by 73.4% in an MDA-MB-468 mouse xenograft model.

References

1.Wang, J., Li, H., He, G., et al.Discovery of novel dual poly(ADP-ribose)polymerase (PARP) and phosphoinositide 3-kinase (PI3K) inhibitors as a promising strategy for cancer therapyJ. Med. Chem.63(1)122-139(2019)

CAY10749 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10749 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32820 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32002 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 6516 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62163 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24649 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7979 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
CAY10749 PARP/PI3K-IN-1 4-(3-(2-(6-Amino-4-(trifluoromethyl)pyridin-3-yl)-4-morpholino-5678-tetrahydropyrido-[34-d]pyrimidine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one PARP/PI3K IN 1,PARP/PI-3K-IN-1,PARP/PI3KIN1 4-[[3-[[2-[6-amino-4-(trifluoromethyl)-3-pyridinyl]-5,8-dihydro-4-(4-morpholinyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone 2337386-47-5