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ChemicalBook >> CAS DataBase List >>Calcipotriol Monohydrate

Calcipotriol Monohydrate

CAS No.
147657-22-5
Chemical Name:
Calcipotriol Monohydrate
Synonyms
Calcipotriol monohydrate CRS;CALCIPOTRIOL MONOHYDRATE;Calcipotriol (Calcipotriene) Monohydrate;(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol;(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate;1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,hydrate (1:1), (1R,3S,5Z)-
CBNumber:
CB8588339
Molecular Formula:
C27H42O4
Molecular Weight:
430.63
MDL Number:
MFCD10567086
MOL File:
147657-22-5.mol
Last updated:2024-10-30 18:52:02

Calcipotriol Monohydrate Properties

storage temp. 4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form Powder
color White to off-white
Stability Hygroscopic, Light sensitive
InChIKey XBKHACNRWFKJNC-IZXATKCONA-N
SMILES C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|
FDA UNII S7499TYY6G

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H310
Precautionary statements  P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501
NFPA 704
0
4 0

Calcipotriol Monohydrate price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009599 Calcipotriol (hydrate) 147657-22-5 10mg $73 2024-03-01 Buy
Cayman Chemical 10009599 Calcipotriol (hydrate) 147657-22-5 500mg $2505 2024-03-01 Buy
Cayman Chemical 10009599 Calcipotriol (hydrate) 147657-22-5 50mg $324 2024-03-01 Buy
Cayman Chemical 10009599 Calcipotriol (hydrate) 147657-22-5 100mg $575 2024-03-01 Buy
TRC C144230 CalcipotriolMonohydrate 147657-22-5 25mg $825 2021-12-16 Buy
Product number Packaging Price Buy
10009599 10mg $73 Buy
10009599 500mg $2505 Buy
10009599 50mg $324 Buy
10009599 100mg $575 Buy
C144230 25mg $825 Buy

Calcipotriol Monohydrate Chemical Properties,Uses,Production

Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Chemical Properties

White or almost white, crystalline powder.

Uses

Vitamin D analogue.

Definition

ChEBI: A hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.

Calcipotriol Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 146)Suppliers
Supplier Tel Email Country ProdList Advantage
HangZhou RunYan Pharma Technology Co.,LTD.
+8618882027439 sales2@runyanpharma.com China 302 58
ChemExpress
+86-021-58950125 +86-021-58950125; info@chemexpress.com China 720 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20288 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 18648 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21639 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29886 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887 sales@finerchem.com China 2964 58

View Lastest Price from Calcipotriol Monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Calcipotriol Monohydrate pictures 2024-10-31 Calcipotriol Monohydrate
147657-22-5
US $0.00-0.00 / g/Bag 1g 97.5% 50g WUHAN FORTUNA CHEMICAL CO., LTD
Calcipotriol Monohydrate pictures 2024-10-31 Calcipotriol Monohydrate
147657-22-5
US $0.00-0.00 / g 10g 99% 10000 HangZhou RunYan Pharma Technology Co.,LTD.
Calcipotriol monohydrate pictures 2024-10-30 Calcipotriol monohydrate
147657-22-5
US $30.00-77.00 / mg 99.57% 10g TargetMol Chemicals Inc.
CALCIPOTRIOL MONOHYDRATE (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol hydrate (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-Cyclohexanediol monohydrate 1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,hydrate (1:1), (1R,3S,5Z)- Calcipotriol (Calcipotriene) Monohydrate (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate Calcipotriol monohydrate CRS 147657-22-5 C27H40O3H2O API API intermediates