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ChemicalBook >> CAS DataBase List >>ERK1/2 inhibitor 1

ERK1/2 inhibitor 1

CAS No.
2095719-90-5
Chemical Name:
ERK1/2 inhibitor 1
Synonyms
ERK1/2 INHIBITOR 1;ERK1/2 inhibitor 1, 10 mM in DMSO;ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1;(R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide;2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-
CBNumber:
CB85540361
Molecular Formula:
C29H32ClN5O4
Molecular Weight:
550.06
MDL Number:
MFCD31813665
MOL File:
2095719-90-5.mol
Last updated:2025-04-17 18:22:24

ERK1/2 inhibitor 1 Properties

Density 1.344±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (454.50 mM; Need ultrasonic)
pka 13.73±0.46(Predicted)
form Solid
color Off-white to light yellow

ERK1/2 inhibitor 1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0044721 ERK1/2inhibitor1 99.16% 2095719-90-5 5mg $650 2021-12-16 Buy
ChemScene CS-0044721 ERK1/2inhibitor1 99.16% 2095719-90-5 10mg $980 2021-12-16 Buy
ChemScene CS-0044721 ERK1/2inhibitor1 99.16% 2095719-90-5 50mg $2550 2021-12-16 Buy
ChemScene CS-0044721 ERK1/2inhibitor1 99.16% 2095719-90-5 100mg $3550 2021-12-16 Buy
Product number Packaging Price Buy
CS-0044721 5mg $650 Buy
CS-0044721 10mg $980 Buy
CS-0044721 50mg $2550 Buy
CS-0044721 100mg $3550 Buy

ERK1/2 inhibitor 1 Chemical Properties,Uses,Production

Uses

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].

Biological Activity

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1]. ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].

IC 50

ERK2: 3.0 nM (IC50); ERK1

References

[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992.

ERK1/2 inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

ERK1/2 inhibitor 1 Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38662 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Shanghai Anyinuo Biomedical Technology Co., Ltd. 021-34625901 18018851262; 420970979@qq.com China 5854 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10523 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24856 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 4997 58

View Lastest Price from ERK1/2 inhibitor 1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ERK1/2 inhibitor 1 pictures 2024-11-13 ERK1/2 inhibitor 1
2095719-90-5
 US $128.00-465.00 / mg 99.09% 10g TargetMol Chemicals Inc.
ERK1/2 inhibitor 1 pictures 2024-11-13 ERK1/2 inhibitor 1
2095719-90-5
 US $128.00-465.00 / mg 99.09% 10g TargetMol Chemicals Inc.

ERK1/2 inhibitor 1 Spectrum

ERK1/2 INHIBITOR 1 2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)- ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1 (R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide ERK1/2 inhibitor 1, 10 mM in DMSO 2095719-90-5 C29H32ClN5O4