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ChemicalBook >> CAS DataBase List >>SIMVASTATIN, SODIUM SALT

SIMVASTATIN, SODIUM SALT

CAS No.
101314-97-0
Chemical Name:
SIMVASTATIN, SODIUM SALT
Synonyms
Simvastati;Simvasatin Ep Imp A;SIMVASTATIN, SODIUM SALT;FYSMQCWXGBXWLB-VMCZNHHFSA-M;Simvastatin Impurity 1（EP-A）;Simvastatin Acid Sodium Salt;Simvastatin hydroxy acid sodium;Simvastatin Impurity as Sodium Salt;SimvastatinEPImpurityA-d6SodiumSalt;SIMVASTATIN HYDROXY ACID SODIUM SALT
CBNumber:
CB8320771
Molecular Formula:
C25H41NaO6
Molecular Weight:
460.59
MDL Number:
MFCD04974206
MOL File:
Mol file
MSDS File:
SDS
Last updated:2024-10-28 23:16:16

SIMVASTATIN, SODIUM SALT Properties

Melting point >122°C (dec.)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form White powder solid.
color White to Pale Beige
Stability Hygroscopic
FDA UNII 2L6JSY5YGL

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H303-H361
Precautionary statements  P201-P202-P280-P312-P405-P501

SIMVASTATIN, SODIUM SALT price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10010345 Simvastatin (sodium salt) ≥98% 101314-97-0 1mg $36 2024-03-01 Buy
Cayman Chemical 10010345 Simvastatin (sodium salt) ≥98% 101314-97-0 5mg $155 2024-03-01 Buy
Cayman Chemical 10010345 Simvastatin (sodium salt) ≥98% 101314-97-0 10mg $274 2024-03-01 Buy
Cayman Chemical 10010345 Simvastatin (sodium salt) ≥98% 101314-97-0 25mg $595 2024-03-01 Buy
TRC S485050 SimvastatinHydroxyAcidSodiumSalt 101314-97-0 25mg $370 2021-12-16 Buy
Product number Packaging Price Buy
10010345 1mg $36 Buy
10010345 5mg $155 Buy
10010345 10mg $274 Buy
10010345 25mg $595 Buy
S485050 25mg $370 Buy

SIMVASTATIN, SODIUM SALT Chemical Properties,Uses,Production

Description

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 μM) and potentiates apoptosis in human myeloid leukemia cells. It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells. Formulations containing simvastatin have been used in the treatment of dyslipidemias.

Uses

Simvastatin Hydroxy Acid Sodium Salt is a metabolite of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.

in vitro

previous study found that simvastatin could inhibit the incorporation of 14c-acetate to 14c-sterol with an ic50 value of 15 nm in cultured hep g2 cells. in addition, simvastatin was found to be a potent inhibitor of cholesterol synthesis in cultured liver cells, whereas pravastatin inhibited cholesterol synthesis in liver cells only after these cells had been digested by collagenase [1].

in vivo

animal study showd that rats orally dosed with simvastatin had lower plasma cholesterol levels after 4 days of treatment. at the level of 0.02% of the diet, simvastatin lowered plasma cholesterol levels in rats by 64%. moreove, in dogs, simvastatin at a daily oral dosage of 8 mg/kg lower levels of plasma cholesterol. at this dosage, simvastatin was slightly more potent than lovastatin and the levels of plasma cholesterol in these dogs returned to pretreatment levels after stopping the treatment [1].

References

[1] chao, y. ,chen, j.s.,hunt, v.m., et al. lowering of plasma cholesterol levels in animals by lovastatin and simvastatin. european journal of clinical pharmacology 40, s11-s14 (1991).
[2] s martande s, kumari m, pradeep ar, pal singh s, kumar suke d. ncomparative evaluation of efficacy of subgingivally delivered 1.2% atorvastatin and 1.2% simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial. j dent res dent clin dent prospects. 2017 winter;11(1):18-25.

5856-77-9
101314-97-0
Synthesis of SIMVASTATIN, SODIUM SALT from 2,2-Dimethylbutyryl chloride

SIMVASTATIN, SODIUM SALT Preparation Products And Raw materials

Global( 82)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30241 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11922 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19863 58
Guangzhou PI PI Biotech Inc 020-81716320 +86-13602409664 Sales@pipitech.com China 3633 55

View Lastest Price from SIMVASTATIN, SODIUM SALT manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Simvastatin EP Impurity A-d6 Sodium Salt pictures 2024-10-28 Simvastatin EP Impurity A-d6 Sodium Salt
US $0.00-0.00 / mg 10g TargetMol Chemicals Inc.
SIMVASTATIN HYDROXY ACID SODIUM SALT SIMVASTATIN, SODIUM SALT IMp. A (EP) as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt Simvastatin Impurity as Sodium Salt Simvastati SiMvastatin IMp. A (EP) as SodiuM Salt sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate Simvastatin hydroxyl acid sodium salt-d6 Simvastatin EP Impurity A Sodium Salt FYSMQCWXGBXWLB-VMCZNHHFSA-M Sodium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate Simvastatin Impurity 1(Simvastatin EP Impurity A) Simvastatin Impurity 1（EP-A） Simvastatin hydroxy acid sodium Simvasatin Ep Imp A Simvasatin EP Impurity A/ Simvasatin Related Compound A (Simvastatin Sodium/ Tenivastatin Sodium) Simvastatin hydroxyl acid D6 Sodium salt Simvastatin EP Impurity AQ: What is Simvastatin EP Impurity A Q: What is the CAS Number of Simvastatin EP Impurity A Q: What is the storage condition of Simvastatin EP Impurity A Q: What are the applications of Simvastatin EP Impurity A Simvastatin Acid Sodium Salt Simvastatin Impurity A sodium salt（EP） SimvastatinEPImpurityA-d6SodiumSalt Simvastatin Impurity A as Sodium Salt Simvastatin EP Impurity A as Sodium Salt Simvastatin Impurity 1 Sodium Salt(Simvastatin EP Impurity A Sodium Salt) 1-Naphthaleneheptanoic acid,8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-b,d-dihydroxy-2,6-dimethyl-, monosodium salt, [1S-[1a(bS*,dS*),2a,6b,8b,8aa]]- Sodium (3R,5R)-7-((1S,2S,6R,8S,8aR)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate 101314-97-0 12009-77-6 C25H39O6Na