PXD-101
- CAS No.
- 866323-14-0
- Chemical Name:
- PXD-101
- Synonyms
- Belista;Bellista;Belinostat（E）;Belinostat Impurity;Belinostat, 10 mM in DMSO;PXD101;PX105684;PXD-101;PXD 101;PX-105684;3-[3-(phenylsulfamoyl)phenyl]prop-2-enehydroxamic acid;(e)-n-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide;(2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide;2-PropenaMide, N-hydroxy-3-[3-[(phenylaMino)sulfonyl]phenyl]-, (2E)-
- CBNumber:
- CB82628305
- Molecular Formula:
- C15H14N2O4S
- Molecular Weight:
- 318.35
- MDL Number:
- MOL File:
- 866323-14-0.mol
- MSDS File:
- SDS
| Melting point | 172 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Density | 1.427±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO:64.0(Max Conc. mg/mL);201.4(Max Conc. mM) |
| form | powder to crystal |
| pka | 8.27±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| FDA UNII | F4H96P17NZ |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H340-H361f-H373 |
| Precautionary statements | P201-P202-P260-P280-P308+P313-P405 |
| HS Code | 2935.90.6000 |
PXD-101 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3010 | Belinostat ≥98% (HPLC) | 866323-14-0 | 10MG | $94.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3010 | Belinostat ≥98% (HPLC) | 866323-14-0 | 50MG | $381 | 2024-03-01 | Buy |
| TCI Chemical | B5888 | Belinostat | 866323-14-0 | 25MG | $64 | 2024-03-01 | Buy |
| TCI Chemical | B5888 | Belinostat | 866323-14-0 | 100MG | $176 | 2024-03-01 | Buy |
| ChemScene | CS-0453 | Belinostat 99.94% | 866323-14-0 | 50mg | $180 | 2021-12-16 | Buy |
PXD-101 Chemical Properties,Uses,Production
Uses
Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
Definition
ChEBI: Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. It has a role as an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a hydroxamic acid, a sulfonamide and an olefinic compound.
Biological Activity
Belinost at (PX105684; PXD101) is a potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 41/125/30/216 nM, class IIA HDAC4/7/9 = 115/67/128 nM, class IIB HDAC6 = 82 nM) with anti-cancer efficacy in vitro and in vivo.
in vivo
Treatment of nude mice bearing human ovarian and colon tumor xenografts with Belinostat (10-40 mg/kg/day i.p.) daily for 7 days causes a significant dose-dependent growth delay with no obvious signs of toxicity to the mice. Growth delay is also observed for xenografts of cisplatin-resistant ovarian tumor cells. A marked increase in acetylation of H4 is detected in blood and tumor of mice 3 h after treatment with Belinostat (PXD101). The inhibition of growth of human tumor xenografts in mice, with no apparent toxicity[1]. Belinostat (PXD101) displays single-agent antitumor activity on human A2780 ovarian cancer s.c. xenografts which is enhanced via combination therapy with Carboplatin[2].
IC 50
HDAC6: 82 nM (IC50); HDAC: 27 nM (IC50, Hela cell)
References
[1] Plumb JA, et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histonedeacetylase inhibitor PXD101. Mol Cancer Ther. 2003 Aug;2(8):721-8. PMID:12939461
[2] Qian X, et al. Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies. Mol Cancer Ther. 2006 Aug;5(8):2086-95. DOI:10.1158/1535-7163.MCT-06-0111
[3] Chia S, et al. Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time. Nat Commun. 2017 Sep 5;8(1):435. DOI:10.1038/s41467-017-00451-5
PXD-101 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Moxin Chemicals | +8617320513646 | Anna@molcoo.com | China | 9986 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29856 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618501500038 | 3899766280@qq.com | China | 26362 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10983 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
View Lastest Price from PXD-101 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-13 | Belinostat Impurity
866323-14-0
|
US $0.00-0.00 / mg | 10mg | 95%+ | 10000000 | Moxin Chemicals | |
 |
2025-05-06 | Belinostat
866323-14-0
|
US $40.00-98.00 / mg | 99.75% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | PXD-101
866323-14-0
|
US $1.00 / KG | 1KG | 98-100% | 100KG | Career Henan Chemical Co |
-
- Belinostat Impurity
866323-14-0
- US $0.00-0.00 / mg
- 95%+
- Moxin Chemicals
-
- Belinostat
866323-14-0
- US $40.00-98.00 / mg
- 99.75%
- TargetMol Chemicals Inc.
-
- PXD-101
866323-14-0
- US $1.00 / KG
- 98-100%
- Career Henan Chemical Co