成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> CAS DataBase List >>TCS JNK 6o

TCS JNK 6o

CAS No.
894804-07-0
Chemical Name:
TCS JNK 6o
Synonyms
TCS JNK 6o;JNK Inhibitor VIII;TCS JNK 6o(JNK Inhibitor VIII);JNK INHIBITOR VIII (TCS JNK 6O);JNK Inhibitor VIII, 10 mM in DMSO;JNK,inhibit,Inhibitor,JNK Inhibitor VIII;JNK inhibitor VIII - JNK inhibitor compound 6o;N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide;Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-;N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
CBNumber:
CB82535702
Molecular Formula:
C18H20N4O4
Molecular Weight:
356.38
MDL Number:
MFCD19690908
MOL File:
894804-07-0.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02

TCS JNK 6o Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form crystalline solid
color White to off-white
UNSPSC Code 41116133
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

TCS JNK 6o price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15946 JNK Inhibitor VIII ≥98% 894804-07-0 5mg $101 2024-03-01 Buy
Cayman Chemical 15946 JNK Inhibitor VIII ≥98% 894804-07-0 1mg $55 2023-06-20 Buy
Cayman Chemical 15946 JNK Inhibitor VIII ≥98% 894804-07-0 10mg $192 2024-03-01 Buy
Tocris 3222 TCSJNK6o ≥98%(HPLC) 894804-07-0 10 $233 2021-12-16 Buy
Tocris 3222 TCSJNK6o ≥98%(HPLC) 894804-07-0 50 $990 2021-12-16 Buy
Product number Packaging Price Buy
15946 5mg $101 Buy
15946 1mg $55 Buy
15946 10mg $192 Buy
3222 10 $233 Buy
3222 50 $990 Buy

TCS JNK 6o Chemical Properties,Uses,Production

Description

c-Jun amino terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. They have been implicated in neurodegeneration, rheumatoid arthritis, inflammation, cancer, and diabetes. JNK1 and JNK2 are widely expressed throughout the body whereas JNK3 is predominantly distributed in the brain. JNK Inhibitor VIII is an aminopyridine compound that inhibits JNK1, JNK2, and JNK3 with Ki values of 2, 4, and 52 nM, respectively. It has been reported to inhibit the phosphorylation of the JNK substrate c-Jun in HepG2 cells (EC50 = 920 nM) without affecting the expression of IL-6, IL-8, or COX-2.

Uses

JNK Inhibitor VIII is an inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release.

in vitro

cs jnk 6o, in a dose-dependent manner, inhibits phosphorylation of c-jun (ec50 = 920 nm) and prevents collagen-induced platelet aggregation. at low collagen concentrations (0.2 and 0.5 μg/ml), platelet aggregation was totally or partially impaired by 10 μm cs jnk 6o, whereas at a high collagen concentration (5 μg/ml), tcs jnk 6o had no effect [2].

in vivo

. pharmacokinetic profiles were studied for tcs jnk 6o in sprague-dawley rats. tcs jnk 6o showed a short half-life of about 1 hour, with barely measurable bioavailability and rapid clearance. microsomal incubation studies revealed that the oxidative metabolism of tcs jnk 6o was very rapid [1]

IC 50

45 nm for jnk1 and 160 nm for jnk2 [1]

storage

Store at +4°C

References

[1] szczepankiewicz bg1, kosogof c, nelson lt, liu g, liu b, zhao h, serby md, xin z, liu m, gum rj, haasch dl, wang s, clampit je, johnson ef, lubben th, stashko ma, olejniczak et, sun c, dorwin sa, haskins k, abad-zapatero c, fry eh, hutchins cw, sham hl, rondinone cm, trevillyan jm. aminopyridine-based c-jun n-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. j med chem. 2006 jun 15;49(12):3563-80.
[2] kauskot a, adam f, mazharian a, ajzenberg n, berrou e, bonnefoy a, rosa jp, hoylaerts mf, bryckaert m. involvement of the mitogen-activated protein kinase c-jun nh2-terminal kinase 1 in thrombus formation. j biol chem. 2007 nov 2;282(44):31990-9.

TCS JNK 6o Preparation Products And Raw materials

Raw materials

Preparation Products

TCS JNK 6o Suppliers

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30232 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070 info@chemlin.com.cn China 19185 64
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14055 65

View Lastest Price from TCS JNK 6o manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JNK Inhibitor VIII pictures 2024-11-17 JNK Inhibitor VIII
894804-07-0
 US $55.00-197.00 / mg 98.93% 10g TargetMol Chemicals Inc.

894804-07-0(TCS JNK 6o)Related Search:

TCS JNK 6o JNK Inhibitor VIII N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide JNK INHIBITOR VIII (TCS JNK 6O) N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide JNK inhibitor VIII - JNK inhibitor compound 6o Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy- TCS JNK 6o(JNK Inhibitor VIII) JNK,inhibit,Inhibitor,JNK Inhibitor VIII JNK Inhibitor VIII, 10 mM in DMSO 894804-07-0