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ChemicalBook >> CAS DataBase List >>1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)-

1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)-

CAS No.
1436695-49-6
Chemical Name:
1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)-
Synonyms
VMAT2INI HCl;VMAT2 IN I HCl;VMAT2-IN-I HCl;VMAT2INI Hydrochloride;VMAT2 IN I Hydrochloride;VMAT2-IN-I Hydrochloride;VMAT2INI HCl,VMAT2 IN I HCl,VMAT-2-IN-I HCl;1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)-
CBNumber:
CB810778320
Molecular Formula:
C25H32ClF4NO4
Molecular Weight:
521.98
MDL Number:
MOL File:
1436695-49-6.mol
Last updated:2025-04-18 09:52:46

1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)- Chemical Properties,Uses,Production

Description

VMAT2-IN-I HCl is a vesicular monoamine transporter-2 (VMAT2) inhibitor, with 15-?fold greater affinity than GZ-?793A.

Uses

VMAT2-IN-4 (compound 11) is a vesicular monoamine transporter-2 (VMAT2) inhibitor. VMAT2-IN-4 inhibits [3H]-DTBZ binding (Ki = 560 nM). VMAT2-IN-4 inhibits [3H]-DA (Ki = 45 nM) from entering vesicles and being taken up by cells. VMAT2-IN-4 can be used in methamphetamine addiction research[1].

IC 50

VMAT2

References

[1] Penthala NR, et al. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2). Bioorg Med Chem Lett. 2013 Jun 1;23(11):3342-5. DOI:10.1016/j.bmcl.2013.03.092

1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)- Preparation Products And Raw materials

Raw materials

Preparation Products

1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32265 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19938 58

View Lastest Price from 1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VMAT2-IN-I HCl pictures 2024-10-28 VMAT2-IN-I HCl
1436695-49-6
 US $2120.00-2780.00 / mg 10g TargetMol Chemicals Inc.
  • VMAT2-IN-I HCl pictures
  • VMAT2-IN-I HCl
    1436695-49-6
  • US $2120.00-2780.00 / mg
  • TargetMol Chemicals Inc.
1,2-Propanediol, 3-[(2R,5S)-2,5-bis[2-[4-(difluoromethoxy)phenyl]ethyl]-1-pyrrolidinyl]-, hydrochloride (1:1), (2R)- VMAT2 IN I HCl VMAT2 IN I Hydrochloride VMAT2INI HCl VMAT2-IN-I HCl VMAT2INI Hydrochloride VMAT2-IN-I Hydrochloride VMAT2INI HCl,VMAT2 IN I HCl,VMAT-2-IN-I HCl 1436695-49-6 C25H32ClF4NO4