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ChemicalBook >> CAS DataBase List >>Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-

CAS No.
2313525-90-3
Chemical Name:
Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-
Synonyms
LEI110, 10 mM in DMSO;2-Oxo-5-phenyl-N-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethyl)pentanamide;Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-;HepG2 cells,inhibit,thiol hydrolases,LEI110,Inhibitor,LEI-110,lipolysis,Phospholipase,LEI 110
CBNumber:
CB78843943
Molecular Formula:
C25H23F3N2O3
Molecular Weight:
456.47
MDL Number:
MOL File:
2313525-90-3.mol
Last updated:2025-04-30 17:58:12

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Properties

Density 1.247±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Ethanol: soluble
form A solid
pka 12.15±0.46(Predicted)
color Light yellow to yellow

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Chemical Properties,Uses,Production

Uses

LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells[1].

Biological Activity

LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2; IC50 = 100 nM).1 It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 μM) decreases arachidonic acid levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.

References

1.Zhou, J., Mock, E.D., Martella, A., et al.Activity-based protein profiling identifies α-ketoamides as inhibitors for phospholipase A2 group XVIACS Chem. Biol.14(2)164-169(2019)

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Suppliers

Global( 35)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38662 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Chengdu Chuangkecheng Biological Technology Co., Ltd. 028-028-0000000 13008177686 sales@ckcbiotech.com China 840 55
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 996 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58

View Lastest Price from Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LEI110 pictures 2025-04-30 LEI110
2313525-90-3
 US $97.00-313.00 / mg 98.8% 10g TargetMol Chemicals Inc.
  • LEI110 pictures
  • LEI110
    2313525-90-3
  • US $97.00-313.00 / mg
  • 98.8%
  • TargetMol Chemicals Inc.
Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- HepG2 cells,inhibit,thiol hydrolases,LEI110,Inhibitor,LEI-110,lipolysis,Phospholipase,LEI 110 LEI110, 10 mM in DMSO 2-Oxo-5-phenyl-N-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethyl)pentanamide 2313525-90-3