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ChemicalBook >> CAS DataBase List >>Dot1L-IN-4

Dot1L-IN-4

CAS No.
2565705-02-2
Chemical Name:
Dot1L-IN-4
Synonyms
Dot1L- IN-4;QQN05022(Dot1L-IN-4);H3K79,Histone Methyltransferase,histone,methyltransferase,lysine,DOT1L,Dot1L IN 4,Inhibitor,Dot-1L-IN-4,Dot1LIN4,inhibit;N1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine;1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-;N1-[(S)-(3-chloropyridin-2-yl)(2,2-difluoro-2H-1,3-benzodioxol-4-yl)methyl]-4-methanesulfonyl-N2-[4-methoxy-6-(piperazin-1-yl)-1,3,5-triazin-2-yl]benzene-1,2-diamine
CBNumber:
CB78364259
Molecular Formula:
C28H27ClF2N8O5S
Molecular Weight:
661.08
MDL Number:
MFCD33023947
MOL File:
2565705-02-2.mol
Last updated:2024-07-02 08:55:17

Dot1L-IN-4 Properties

Boiling point 792.1±70.0 °C(Predicted)
Density 1.58±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (378.17 mM; Need ultrasonic)
form A solid
pka 8.67±0.10(Predicted)
color White to light yellow

Dot1L-IN-4 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0109501 Dot1L-IN-4 99.60% 2565705-02-2 5mg $580 2021-12-16 Buy
ChemScene CS-0109501 Dot1L-IN-4 99.60% 2565705-02-2 10mg $980 2021-12-16 Buy
ChemScene CS-0109501 Dot1L-IN-4 99.60% 2565705-02-2 25mg $1900 2021-12-16 Buy
ChemScene CS-0109501 Dot1L-IN-4 99.60% 2565705-02-2 50mg $3200 2021-12-16 Buy
ChemScene CS-0109501 Dot1L-IN-4 99.60% 2565705-02-2 100mg $5000 2021-12-16 Buy
Product number Packaging Price Buy
CS-0109501 5mg $580 Buy
CS-0109501 10mg $980 Buy
CS-0109501 25mg $1900 Buy
CS-0109501 50mg $3200 Buy
CS-0109501 100mg $5000 Buy

Dot1L-IN-4 Chemical Properties,Uses,Production

Biological Activity

Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM[1]. Dot1L-IN-4 (Compound 10) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=1.7 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=33 nM). Dot1L-IN-4 also inhibits mixed lineage leukemia (MLL) with an IC50 of 99 μM[1]. Dot1L-IN-4 (Compound 10; 300 mg/kg; p.o.; qd) is not tolerated at such a high dose by tumor xenograft bearing mice, and at a 6-fold reduced dose, the tumor growth as well as the HOXA9 reporter gene mRNA are reduced only by less than half as compared to control animals[1].

References

[1]. Frédéric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.

Dot1L-IN-4 Preparation Products And Raw materials

Raw materials

Preparation Products

Dot1L-IN-4 Suppliers

Global( 23)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32820 60
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38463 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Wuhan Acumen Bio-Technology Co.,ltd 027-027-16602739303 16602739303 673003916@qq.com China 3059 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4456 55
Shanghai JingRon Chemical Technology Co., Ltd. 021-60546673 13701861782 kuanga111@sina.com China 820 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8014 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2982 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 6521 58
1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)- Dot1L- IN-4 QQN05022(Dot1L-IN-4) N1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine H3K79,Histone Methyltransferase,histone,methyltransferase,lysine,DOT1L,Dot1L IN 4,Inhibitor,Dot-1L-IN-4,Dot1LIN4,inhibit N1-[(S)-(3-chloropyridin-2-yl)(2,2-difluoro-2H-1,3-benzodioxol-4-yl)methyl]-4-methanesulfonyl-N2-[4-methoxy-6-(piperazin-1-yl)-1,3,5-triazin-2-yl]benzene-1,2-diamine 2565705-02-2 C28H27ClF2N8O5S