L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl-
- CAS No.
- 1417302-71-6
- Chemical Name:
- L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl-
- Synonyms
- GLP-1(32-36)amide;L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl-
- CBNumber:
- CB78231407
- Molecular Formula:
- C25H50N10O5
- Molecular Weight:
- 570.73
- MDL Number:
- MFCD33023596
- MOL File:
- 1417302-71-6.mol
L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl- price
L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl- Chemical Properties,Uses,Production
Uses
GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice[1][2].
in vivo
GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice[2].
GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice[2].
GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice[3].
| Animal Model: | Male KM mice (6-8 weeks; 18-22 g) injected with STZ[2] |
| Dosage: | 1 μmol/kg |
| Administration: | I.p. once daily for 21 days |
| Result: | Signi?cantly lowered the cumulative values of food and water intake. Lowered fasting glucose. Reduced the level of Hemoglobin A1c (HbA1c). Improved glucose tolerance. Suppressed body weight gain. |
References
[1] Elahi D, et, al. GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep;59:20-4. DOI:10.1016/j.peptides.2014.06.004
[2] Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015 Dec;86(6):1482-90. DOI:10.1111/cbdd.12615
[3] Tomas E, et, al. GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul;64(7):2409-19. DOI:10.2337/db14-1708
L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl- Preparation Products And Raw materials
Raw materials
Preparation Products
L-Argininamide, L-leucyl-L-valyl-L-lysylglycyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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