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ChemicalBook >> CAS DataBase List >>BMS-654457 (BMS654457)

BMS-654457 (BMS654457)

CAS No.
1004551-41-0
Chemical Name:
BMS-654457 (BMS654457)
Synonyms
BMS-654457 (BMS654457);[1,1'-Biphenyl]-2-carboxylic acid, 4-(aminocarbonyl)-3'-[(2S,4R)-6-(aminoiminomethyl)-1,2,3,4-tetrahydro-4-methyl-4-phenyl-2-quinolinyl]-5'-[(3-methyl-1-oxobutyl)amino]-
CBNumber:
CB74844566
Molecular Formula:
C36H37N5O4
Molecular Weight:
603.71
MDL Number:
MFCD28411420
MOL File:
1004551-41-0.mol
Last updated:2025-04-18 09:52:41

BMS-654457 (BMS654457) Properties

Density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 3?+-.0.36(Predicted)

BMS-654457 (BMS654457) Chemical Properties,Uses,Production

Description

BMS-654457 is a novel reversible and direct inhibitor of factor Xia.

Uses

BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively.

in vivo

BMS-654457 is effective in the prevention of arterial thrombosis in rabbits with limited effects on bleeding time. BMS-654457 is a promising antithrombotic therapy with a wide therapeutic window[1].

References

[1] Wong PC, et al. In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa. J Thromb Thrombolysis. 2015 Nov;40(4):416-23. DOI:10.1007/s11239-015-1258-7

BMS-654457 (BMS654457) Preparation Products And Raw materials

Raw materials

Preparation Products

BMS-654457 (BMS654457) Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32265 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38659 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19930 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 18215 58

View Lastest Price from BMS-654457 (BMS654457) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BMS-654457 pictures 2024-10-28 BMS-654457
1004551-41-0
 US $1970.00-2580.00 / mg 10g TargetMol Chemicals Inc.
  • BMS-654457 pictures
  • BMS-654457
    1004551-41-0
  • US $1970.00-2580.00 / mg
  • TargetMol Chemicals Inc.
BMS-654457 (BMS654457) [1,1'-Biphenyl]-2-carboxylic acid, 4-(aminocarbonyl)-3'-[(2S,4R)-6-(aminoiminomethyl)-1,2,3,4-tetrahydro-4-methyl-4-phenyl-2-quinolinyl]-5'-[(3-methyl-1-oxobutyl)amino]- 1004551-41-0