ChemicalBook >> CAS DataBase List >>4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl structure

CAS No.: 2093386-50-4

Chemical Name:: 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Synonyms: Thalidomide-NH-C6-NH2;Thalidomide-4-NH-C6-NH2;4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl;1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[(6-aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

CBNumber:: CB74796319

Molecular Formula:: C19H24N4O4

Molecular Weight:: 372.42

MDL Number:: MFCD31729298

MOL File:: 2093386-50-4.mol

Last updated:2023-07-14 17:45:51

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4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Properties

Boiling point	648.2±55.0 °C(Predicted)
Density	1.342±0.06 g/cm3(Predicted)
pka	10.75±0.40(Predicted)

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
DC Chemicals	027581	Thalidomide-NH-C6-NH2	2093386-50-4	001	$400	2021-12-16	Buy
DC Chemicals	027581	Thalidomide-NH-C6-NH2	2093386-50-4	002	$700	2021-12-16	Buy
Acrotein	AS00955	4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneHCl 97%	2093386-50-4	0.5g	$825	2021-12-16	Buy
A1 Biochem Labs	6591785	4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dionehydrochloride 95%	2093386-50-4	2.5g	$1200	2021-12-16	Buy

Product number	Packaging	Price	Buy
027581	001	$400	Buy
027581	002	$700	Buy
AS00955	0.5g	$825	Buy
6591785	2.5g	$1200	Buy

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties,Uses,Production

Biological Activity

Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Preparation Products And Raw materials

Raw materials

Preparation Products

4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Suppliers

Global( 23)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	6795	65
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7787	56
Chengdu HuaNa Chemicals Co., Ltd.	028-86612776; 13699069380	515238037@qq.com	China	965	55
Amatek Scientific Co. Ltd.	0512-56316828	info@amateksci.com	China	28805	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1471	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Nextpeptide Inc	58
Alfa Chemistry	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Daicel Chiral Technologies (China)CO.,LTD	65
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Chengdu HuaNa Chemicals Co., Ltd.	55
Amatek Scientific Co. Ltd.	58
Jilin Province Woda Biotechnology Co., Ltd.	58
DC Chemicals	58

2093386-50-4(4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl)Related Search:

Thalidomide-O-amido-C2-NH2 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione -alkylC5-amine Thalidomide-NH-C6-NH2 TFA

E3 ligase Ligand-Linker Conjugates 15 Thalidomide-O-amido-C2-NH2 Thalidomide-NH-PEG2-C2-NH2 hydrochloride Thalidomide-NH-PEG2-C2-NH2 (TFA) 5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione,

Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]- 1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- 5-[(8-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

5-[(5-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 5-[(7-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-[(10-aminodecyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-

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4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Thalidomide-NH-C6-NH2 1H-Isoindole-1,3(2H)-dione, 4-[(6-aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)- 4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Thalidomide-4-NH-C6-NH2 4-[(6-aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 2093386-50-4

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