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ChemicalBook >> CAS DataBase List >>IRBP (1-20), human

IRBP (1-20), human

CAS No.
298202-25-2
Chemical Name:
IRBP (1-20), human
Synonyms
Irbp (1-20);IRBP (1-20), human;L-Aspartic acid, glycyl-L-prolyl-L-threonyl-L-histidyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-seryl-L-leucyl-L-valyl-L-leucyl-L-α-aspartyl-L-methionyl-L-alanyl-L-lysyl-L-valyl-L-leucyl-L-leucyl-
CBNumber:
CB74713738
Molecular Formula:
C101H164N24O28S
Molecular Weight:
2194.62
MDL Number:
MFCD08274407
MOL File:
298202-25-2.mol
Last updated:2025-04-18 09:52:42

IRBP (1-20), human Properties

Boiling point 2184.9±65.0 °C(Predicted)
Density 1.275±0.06 g/cm3(Predicted)
pka 2.89±0.10(Predicted)
form Solid
color White to off-white

IRBP (1-20), human Chemical Properties,Uses,Production

Uses

IRBP (1-20), human contains a major epitope for the H-2b haplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2b mice[1][2].

in vivo

IRBP (1-20), human TFA induces EAU[2].
For determination of proliferative and cytokine responses, lymph node and spleen cells are collected 21 days after immunization and are stimulated in culture with the appropriate antigen. Cells of C57BL/6 mice and 129/J mice immunized with IRBP (1-20), human TFA proliferated in response to the peptide[2].

Animal Model:C57BL/6 (H-2bb[2]
Dosage:200, 300 μg
Administration:I.h.; After 21 days
Result:C57BL/6 (H-2bb) also developed disease, albeit with a lower average score than C57BL/6.

References

[1] Avichezer D, et al. Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice. Exp Eye Res. 2000;71(2):111‐118. DOI:10.1006/exer.2000.0860
[2] Avichezer D, Silver PB, Chan CC, Wiggert B, Caspi RR. Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci. 2000;41(1):127‐131. PMID:10634611

IRBP (1-20), human Preparation Products And Raw materials

Raw materials

Preparation Products

IRBP (1-20), human Suppliers

Global( 43)Suppliers
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SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Changsha MOL Changes Biotechnology Co., Ltd. 		+8619375158599 info@molchanges.com China 5221 58
Creative Peptides info@creative-peptides.com United States 6083 56
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
L-Aspartic acid, glycyl-L-prolyl-L-threonyl-L-histidyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-seryl-L-leucyl-L-valyl-L-leucyl-L-α-aspartyl-L-methionyl-L-alanyl-L-lysyl-L-valyl-L-leucyl-L-leucyl- IRBP (1-20), human Irbp (1-20) 298202-25-2 C101H164N24O28S