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SB 218795

CAS No.
174635-53-1
Chemical Name:
SB 218795
Synonyms
SB 218795;Sb 218795r;Methyl (R)-2-phenyl-2-(2-phenylquinoline-4-carboxamido)acetate;methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate;(-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide;(-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE;(R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID;Benzeneacetic acid, α-[[(2-phenyl-4-quinolinyl)carbonyl]amino]-, methyl ester, (αR)-;Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphar)-;constriction,SB-218795,Neurokinin Receptor,Inhibitor,neurokinin-3,NK receptor,pupillary,inhibit,Tachykinin receptor,SB218795,SB 218795,NK-3
CBNumber:
CB7376630
Molecular Formula:
C25H20N2O3
Molecular Weight:
396.44
MDL Number:
MFCD00951240
MOL File:
174635-53-1.mol
Last updated:2023-09-04 15:51:00

SB 218795 Properties

Boiling point 623.7±55.0 °C(Predicted)
Density 1.237±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 40 mg/mL, soluble
form solid
pka 11.41±0.46(Predicted)
color white

SAFETY

Risk and Safety Statements

WGK Germany  3

SB 218795 price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 1376 SB218795 ≥99%(HPLC) 174635-53-1 10 $174 2021-12-16 Buy
Tocris 1376 SB218795 ≥99%(HPLC) 174635-53-1 50 $713 2021-12-16 Buy
TRC S155070 SB218795 174635-53-1 50mg $865 2021-12-16 Buy
American Custom Chemicals Corporation API0007579 SB 218795 95.00% 174635-53-1 50MG $1327.97 2021-12-16 Buy
ApexBio Technology B6710 SB218795 174635-53-1 50mg $1362 2021-12-16 Buy
Product number Packaging Price Buy
1376 10 $174 Buy
1376 50 $713 Buy
S155070 50mg $865 Buy
API0007579 50MG $1327.97 Buy
B6710 50mg $1362 Buy

SB 218795 Chemical Properties,Uses,Production

Uses

SB 218795 is an NK3 receptor antagonist.

Definition

ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines.

Biological Activity

Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.

SB 218795 Preparation Products And Raw materials

Raw materials

Preparation Products

SB 218795 Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32080 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9891 58
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 4418 55
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 Sales@ATKchemical.com China 7257 58
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 amber@biochempartner.com China 3061 58

SB 218795 Spectrum

SB 218795 (-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE (R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID (-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphar)- Sb 218795r methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate constriction,SB-218795,Neurokinin Receptor,Inhibitor,neurokinin-3,NK receptor,pupillary,inhibit,Tachykinin receptor,SB218795,SB 218795,NK-3 Benzeneacetic acid, α-[[(2-phenyl-4-quinolinyl)carbonyl]amino]-, methyl ester, (αR)- Methyl (R)-2-phenyl-2-(2-phenylquinoline-4-carboxamido)acetate 174635-53-1