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ChemicalBook >> CAS DataBase List >>DLin-M-C3-DMA

DLin-M-C3-DMA

CAS No.
1224606-06-7
Chemical Name:
DLin-M-C3-DMA
Synonyms
D-Lin-MC3-DMA (MC3);RV28;RV 28;RV-28;DLin-M-C3-DMA;Metalaxyl Impurity 1 (Metalaxyl-M);dilinoleylmethyl 4-(dimethylamino)butanoate;D-LIN-MC3-DMA;DLINMC3DMA;D-LIN-MC-3-DMA;D-LIN-MC3-DMA;Heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate;O-(Z,Z,Z,Z-heptatriaconta-6,9,26,29-tetraen-19-yl)-4-(N,N-dimethylamino)
CBNumber:
CB73382342
Molecular Formula:
C43H79NO2
Molecular Weight:
642.09
MDL Number:
MFCD31657426
MOL File:
1224606-06-7.mol
Last updated:2024-10-28 16:48:35

DLin-M-C3-DMA Properties

Boiling point 670.2±43.0 °C(Predicted)
Density 0.886±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in Ethanol, DMSO, DMF
pka 9.37±0.28(Predicted)
form Liquid
color Colorless to light yellow
FDA UNII Q0J6FQ6FKP

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
3
2 0

DLin-M-C3-DMA price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
BroadPharm BP-25497 D-Lin-MC3-DMA 98% 1224606-06-7 50mg $450 2021-12-16 Buy
BroadPharm BP-25497 D-Lin-MC3-DMA 98% 1224606-06-7 100mg $780 2021-12-16 Buy
DC Chemicals DC10800 DLin-MC3-DMA >98% 1224606-06-7 250mg $1300 2021-12-16 Buy
Ambeed A746322 (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl4-(dimethylamino)butanoate 98% 1224606-06-7 1g $1945 2021-12-16 Buy
Ambeed A746322 (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl4-(dimethylamino)butanoate 98% 1224606-06-7 250mg $572 2021-12-16 Buy
Product number Packaging Price Buy
BP-25497 50mg $450 Buy
BP-25497 100mg $780 Buy
DC10800 250mg $1300 Buy
A746322 1g $1945 Buy
A746322 250mg $572 Buy

DLin-M-C3-DMA Chemical Properties,Uses,Production

Description

D-Lin-MC3-DMA (MC3, DLin-MC3-DMA) is a potent and ionizable cationic lipid. D-Lin-MC3-DMA is used for delivery of siRNA in vivo. DLin-MC3-DMA, or (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate , is one of the most utilized cationic lipids that is used for making Lipid Nano-Particles (LNPs). These lipids, can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into the cytoplasm and represent the most advanced delivery platforms for systemic administration of active molecules.

Uses

DLin-M-C3-DMA is a commonly used drug delivery vehicle for the fabrication of lipid nanoparticles (LNPs), which exert therapeutic effects by encapsulating and delivering siRNA, mRNA, DNA, or small molecules into the cytoplasm of the cell, and is a potent siRNA delivery vehicle.

Biological Activity

DLin-MC3-DMA is an ionizable lipid used in combination with other lipids for encapsulation of RNA and DNA into lipid nanoparticles (LNPs). Administration of DLin-MC3-DMA based LNPs have delivered siRNA and reduced Factor VII levels in mice. Delivery of BCR-ABL siRNA reduced leukemic burden in a mouse model of chronic myeloid leukemia (CML).

storage

Store at -20°C

1169768-28-8
69954-66-1
1224606-06-7
Synthesis of DLin-M-C3-DMA from 6,9,28,31-Heptatriacontatetraen-19-ol, (6Z,9Z,28Z,31Z)- and 4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE
Global( 151)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60
XIAMEN SINOPEG BIOTECH CO., LTD.
+86-0592-7761068 +8617350879715 changaiwei@sinopeg.com China 183 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12829 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18648 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 13486 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32024 58

View Lastest Price from DLin-M-C3-DMA manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D-Lin-MC3-DMA pictures 2024-10-28 D-Lin-MC3-DMA
1224606-06-7
 US $34.00-117.00 / mg ≥98% 10g TargetMol Chemicals Inc.
D-Lin-MC3-DMA pictures 2024-09-06 D-Lin-MC3-DMA
1224606-06-7
 US $0.00-0.00 / g 1g 98% 1g/bottle , 10g/bottle, 100g/bottle XIAMEN SINOPEG BIOTECH CO., LTD.
D-Lin-MC3-DMA pictures 2023-09-28 D-Lin-MC3-DMA
1224606-06-7
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
  • D-Lin-MC3-DMA pictures
  • D-Lin-MC3-DMA
    1224606-06-7
  • US $34.00-117.00 / mg
  • ≥98%
  • TargetMol Chemicals Inc.
  • D-Lin-MC3-DMA pictures
  • D-Lin-MC3-DMA
    1224606-06-7
  • US $0.00-0.00 / g
  • 98%
  • XIAMEN SINOPEG BIOTECH CO., LTD.
  • D-Lin-MC3-DMA pictures
  • D-Lin-MC3-DMA
    1224606-06-7
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd

1224606-06-7(DLin-M-C3-DMA)Related Search:

DLin-M-C3-DMA D-LIN-MC3-DMA;DLINMC3DMA;D-LIN-MC-3-DMA;D-LIN-MC3-DMA (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate Butanoic acid, 4-(dimethylamino)-, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester O-(Z,Z,Z,Z-heptatriaconta-6,9,26,29-tetraen-19-yl)-4-(N,N-dimethylamino) D-Lin-MC3-DMA (MC3) dilinoleylmethyl 4-(dimethylamino)butanoate Heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate Metalaxyl Impurity 1 (Metalaxyl-M) 4-(dimethylamino)-butanoic acid, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester RV 28 RV28 RV-28 1224606-06-7 224606-06-7 C43H79NO2 Intermediates