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ChemicalBook >> CAS DataBase List >>BAY-1082439

BAY-1082439

CAS No.
1375469-38-7
Chemical Name:
BAY-1082439
Synonyms
CS-2422;BAY 2439;BAY-1082439;BAY-1082439; BAY 2439;BAY10-82439; BAY 10-82439; BAY-10-82439; BAY1082439; BAY 1082439; BAY-1082439;(R)-N-(8-(2-hydroxy-3-morpholinopropoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylnicotinamide;3-Pyridinecarboxamide, N-[2,3-dihydro-8-[(2R)-2-hydroxy-3-(4-morpholinyl)propoxy]-7-methoxyimidazo[1,2-c]quinazolin-5-yl]-2-methyl-;N-[8-[[(2R)-2-Hydroxy-3-(morpholin-4-yl)propyl]oxy]-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]-2-methylpyridine-3-carboxamide;BAY 1082439,BAY-1082439,PTEN,inhibit,cancer,oral,Inhibitor,forms,Phosphoinositide 3-kinase,PI3K,Apoptosis,BAY1082439,mutated,PIK3CA,prostate
CBNumber:
CB73147620
Molecular Formula:
C25H30N6O5
Molecular Weight:
494.54
MDL Number:
MFCD31540439
MOL File:
1375469-38-7.mol
Last updated:2025-04-18 09:52:39

BAY-1082439 Properties

Density 1.43±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 5 mg/mL (10.11 mM; ultrasonic and adjust pH to 5 with HCl)
form A solid
pka 10.27±0.20(Predicted)
color White to off-white
FDA UNII 59784ZX4GD

BAY-1082439 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0020548 BAY1082439 99.46% 1375469-38-7 5mg $90 2021-12-16 Buy
ChemScene CS-0020548 BAY1082439 99.46% 1375469-38-7 10mg $150 2021-12-16 Buy
ChemScene CS-0020548 BAY1082439 99.46% 1375469-38-7 25mg $250 2021-12-16 Buy
ChemScene CS-0020548 BAY1082439 99.46% 1375469-38-7 50mg $450 2021-12-16 Buy
ChemScene CS-0020548 BAY1082439 99.46% 1375469-38-7 100mg $750 2021-12-16 Buy
Product number Packaging Price Buy
CS-0020548 5mg $90 Buy
CS-0020548 10mg $150 Buy
CS-0020548 25mg $250 Buy
CS-0020548 50mg $450 Buy
CS-0020548 100mg $750 Buy

BAY-1082439 Chemical Properties,Uses,Production

Uses

BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2].

in vivo

BAY1082439 (75 mg/kg; p.o.; daily for 4 weeks) is effective in preventing Pten-null prostate cancer progression[2].

Animal Model: Pten conditional knockout mouse model (Pb-Cre+;PtenL/L, CP model)[2]
Dosage:75 mg/kg
Administration:P.o.; daily for 4 weeks
Result:Significantly decreased tumor size and P-AKT staining, nearly normal luminal architecture, and a significant reduction of Ki67-positive cells. Significantly inhibit the human prostate cancer growth.

IC 50

PI3Kα; PI3Kβ; PI3Kδ

References

[1] Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445.AM2012-2799.
[2] Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099. DOI:10.1158/1535-7163.MCT-18-0038

BAY-1082439 Preparation Products And Raw materials

Raw materials

Preparation Products

BAY-1082439 Suppliers

Global( 60)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Chemtour Biotech Co., Ltd 		+8617327281506 market@chemtour.com China 1521 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61

View Lastest Price from BAY-1082439 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BAY1082439 pictures 2024-11-19 BAY1082439
1375469-38-7
 US $31.00-72.00 / mg 100% 10g TargetMol Chemicals Inc.
BAY1082439 pictures 2024-11-19 BAY1082439
1375469-38-7
 US $31.00-72.00 / mg 100% 10g TargetMol Chemicals Inc.
BAY-1082439 pictures 2019-12-26 BAY-1082439
1375469-38-7
 US $1.00 / KG 1KG 97%-99.9% 100kg Career Henan Chemical Co
  • BAY1082439 pictures
  • BAY1082439
    1375469-38-7
  • US $31.00-72.00 / mg
  • 100%
  • TargetMol Chemicals Inc.
  • BAY1082439 pictures
  • BAY1082439
    1375469-38-7
  • US $31.00-72.00 / mg
  • 100%
  • TargetMol Chemicals Inc.
  • BAY-1082439 pictures
  • BAY-1082439
    1375469-38-7
  • US $1.00 / KG
  • 97%-99.9%
  • Career Henan Chemical Co
BAY-1082439 BAY 2439 N-[8-[[(2R)-2-Hydroxy-3-(morpholin-4-yl)propyl]oxy]-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]-2-methylpyridine-3-carboxamide BAY-1082439; BAY 2439 (R)-N-(8-(2-hydroxy-3-morpholinopropoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylnicotinamide BAY10-82439; BAY 10-82439; BAY-10-82439; BAY1082439; BAY 1082439; BAY-1082439 CS-2422 BAY 1082439,BAY-1082439,PTEN,inhibit,cancer,oral,Inhibitor,forms,Phosphoinositide 3-kinase,PI3K,Apoptosis,BAY1082439,mutated,PIK3CA,prostate 3-Pyridinecarboxamide, N-[2,3-dihydro-8-[(2R)-2-hydroxy-3-(4-morpholinyl)propoxy]-7-methoxyimidazo[1,2-c]quinazolin-5-yl]-2-methyl- 1375469-38-7