ChemicalBook >> CAS DataBase List >>RG3039
RG3039
- CAS No.
- 1005504-62-0
- Chemical Name:
- RG3039
- Synonyms
- RG3039;CS-2207;EOS-61154;EOS-62326;PF-6687859;PF-6687859 Free;RG-3039; RG3039;RG3039(PF-06687859);PF-06687859/R -3039;Rg3039, 10 mM in DMSO
- CBNumber:
- CB72745524
- Molecular Formula:
- C21H23Cl2N5O
- Molecular Weight:
- 432.35
- MDL Number:
- MFCD28716151
- MOL File:
- 1005504-62-0.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Boiling point | 648.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.375±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:2.0(Max Conc. mg/mL);4.6(Max Conc. mM) |
| form | A solid |
| pka | 7.82±0.30(Predicted) |
| color | White to off-white |
| FDA UNII | KSV93L7URW |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
RG3039 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| DC Chemicals | DC7551 | RG3039(PF-06687859) >98% | 1005504-62-0 | 100mg | $500 | 2021-12-16 | Buy |
| Crysdot | CD11369359 | RG3039(PF-06687859) 95+% | 1005504-62-0 | 100mg | $520 | 2021-12-16 | Buy |
| DC Chemicals | DC7551 | RG3039(PF-06687859) >98% | 1005504-62-0 | 250mg | $1000 | 2021-12-16 | Buy |
| DC Chemicals | DC7551 | RG3039(PF-06687859) >98% | 1005504-62-0 | 1g | $2000 | 2021-12-16 | Buy |
| Crysdot | CD11369359 | RG3039(PF-06687859) 95+% | 1005504-62-0 | 1g | $2080 | 2021-12-16 | Buy |
RG3039 Chemical Properties,Uses,Production
Biological Activity
RG3039 is a brain-penetrant and potent inhibitor against the scavenger mRNA-decapping enzyme DcpS (m7GpppX diphosphatase) in vitro (mouse DcpS IC50 = 3.4 nM) and in mice in vivo (∼90% & ∼80% inhibition of brain DcpS, respectively, 2 h & 72 h post last 3 mg/kg daily ip. from P1 to P10). In a murine severe spinal muscular atrophy (SMA) model, RG3039 (10-20 mg/kg/d ip. from P1 till death) increases SMAΔ7 mice survival (by 26%) and motor function with a ∼50% increase of VGLUT1 synapses number on L3-L5 motor neurons (33.7/WT mice at P13 vs. 17.2/SMA mice without 26.1/SMA mice with RG3039 treatment).
RG3039 Preparation Products And Raw materials
Raw materials
Preparation Products
RG3039 Suppliers
Global( 62)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +86-18055311600 | sales1@nuowei-chem.com | China | 1638 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
1005504-62-0(RG3039)Related Search:
RG3039
RG3039(PF-06687859)
5-[[1-(2,6-Dichlorobenzyl)piperidin-4-yl]methoxy]quinazoline-2,4-diamine
5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diaminedihydrochloride
PF-6687859
2,4-Quinazolinediamine, 5-[[1-[(2,6-dichlorophenyl)methyl]-4-piperidinyl]methoxy]-
CS-2207
RG-3039; RG3039
EOS-62326
EOS-61154
PF-6687859 Free
PF06687859,Inhibitor,PF 06687859,inhibit,Rg-3039,RG 3039,Rg3039
PF-06687859/R -3039
Rg3039, 10 mM in DMSO
1005504-62-0