AHU-377 (heMicalciuM salt)
- CAS No.
- 1369773-39-6
- Chemical Name:
- AHU-377 (heMicalciuM salt)
- Synonyms
- Sacubitril Calcium;Sacubitril hemicalcium;Sacubitril calcium salt;(alphar;LCZ696-1;Sabatrol calcium;AHU377 Calcium Salt;AHU-377 Hemicalcium;Sacubitrial Calcium;LCZ696 Impurity 534-06
- CBNumber:
- CB72685916
- Molecular Formula:
- C48H56CaN2O10
- Molecular Weight:
- 861.04364
- MDL Number:
- MFCD28137893
- MOL File:
- 1369773-39-6.mol
- MSDS File:
- SDS
Melting point | >140°C (dec.) |
---|---|
Density | 1.24g/cm3 at 20℃ |
vapor pressure | 0.001Pa at 20℃ |
storage temp. | -20°C |
solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
form | powder |
color | white to beige |
LogP | -0.66-2.9 at 20℃ and pH2-7 |
FDA UNII | 8F45HCQ47Q |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS09 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301-H400 | |||||||||
Precautionary statements | P273-P301+P310+P330 | |||||||||
RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | |||||||||
NFPA 704 |
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AHU-377 (heMicalciuM salt) price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1380 | Sacubitril calcium salt ≥98% (HPLC) | 1369773-39-6 | 5MG | $112 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1380 | Sacubitril calcium salt ≥98% (HPLC) | 1369773-39-6 | 25MG | $438 | 2023-06-20 | Buy |
Cayman Chemical | 21473 | AHU377 (calcium salt) ≥98% | 1369773-39-6 | 10mg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 21473 | AHU377 (calcium salt) ≥98% | 1369773-39-6 | 25mg | $143 | 2024-03-01 | Buy |
Cayman Chemical | 21473 | AHU377 (calcium salt) ≥98% | 1369773-39-6 | 50mg | $219 | 2024-03-01 | Buy |
AHU-377 (heMicalciuM salt) Chemical Properties,Uses,Production
Uses
Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
Biochem/physiol Actions
Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.
storage
Store at -20°C
AHU-377 (heMicalciuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 375 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18648 | 58 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21639 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29886 | 58 |
View Lastest Price from AHU-377 (heMicalciuM salt) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-30 | Sacubitril hemicalcium salt
1369773-39-6
|
US $33.00-58.00 / mg | 99.93% | 10g | TargetMol Chemicals Inc. | |||
2024-10-16 | Ahu-377 Hemicalcium Salt
1369773-39-6
|
US $0.00 / g | 1g | More Than 99% | 50kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
2023-04-12 | AHU-377 HeMicalciuM Salt
1369773-39-6
|
US $14.00 / Kg/Bag | 1Kg/Bag | 98% | Weekly supply of 1000KG | Wuhan Dujiang Industrial Co., Ltd. |
- Sacubitril hemicalcium salt
1369773-39-6
- US $33.00-58.00 / mg
- 99.93%
- TargetMol Chemicals Inc.
- Ahu-377 Hemicalcium Salt
1369773-39-6
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
- AHU-377 HeMicalciuM Salt
1369773-39-6
- US $14.00 / Kg/Bag
- 98%
- Wuhan Dujiang Industrial Co., Ltd.
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