ChemicalBook >> CAS DataBase List >>AHU-377 (heMicalciuM salt)
AHU-377 (heMicalciuM salt)
- CAS No.
- 1369773-39-6
- Chemical Name:
- AHU-377 (heMicalciuM salt)
- Synonyms
- Sacubitril Calcium;Sacubitril hemicalcium;Sacubitril calcium salt;(alphar;LCZ696-1;Sabatrol calcium;AHU377 Calcium Salt;AHU-377 Hemicalcium;Sacubitrial Calcium;LCZ696 Impurity 534-06
- CBNumber:
- CB72685916
- Molecular Formula:
- C48H56CaN2O10
- Molecular Weight:
- 861.04364
- MDL Number:
- MFCD28137893
- MOL File:
- 1369773-39-6.mol
- MSDS File:
- SDS
Last updated:2024-10-30 18:52:02
| Melting point | >140°C (dec.) |
|---|---|
| Density | 1.24g/cm3 at 20℃ |
| vapor pressure | 0.001Pa at 20℃ |
| storage temp. | -20°C |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | powder |
| color | white to beige |
| LogP | -0.66-2.9 at 20℃ and pH2-7 |
| FDA UNII | 8F45HCQ47Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H400 | |||||||||
| Precautionary statements | P273-P301+P310+P330 | |||||||||
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | |||||||||
| NFPA 704 |
|
AHU-377 (heMicalciuM salt) price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1380 | Sacubitril calcium salt ≥98% (HPLC) | 1369773-39-6 | 5MG | $112 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1380 | Sacubitril calcium salt ≥98% (HPLC) | 1369773-39-6 | 25MG | $438 | 2023-06-20 | Buy |
| Cayman Chemical | 21473 | AHU377 (calcium salt) ≥98% | 1369773-39-6 | 10mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 21473 | AHU377 (calcium salt) ≥98% | 1369773-39-6 | 25mg | $143 | 2024-03-01 | Buy |
| Cayman Chemical | 21473 | AHU377 (calcium salt) ≥98% | 1369773-39-6 | 50mg | $219 | 2024-03-01 | Buy |
AHU-377 (heMicalciuM salt) Chemical Properties,Uses,Production
Uses
Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
Biochem/physiol Actions
Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.
storage
Store at -20°C
AHU-377 (heMicalciuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 281)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 375 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18648 | 58 |
| Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21639 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29886 | 58 |
View Lastest Price from AHU-377 (heMicalciuM salt) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-30 | Sacubitril hemicalcium salt
1369773-39-6
|
US $33.00-58.00 / mg | 99.93% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-16 | Ahu-377 Hemicalcium Salt
1369773-39-6
|
US $0.00 / g | 1g | More Than 99% | 50kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | |
 |
2023-04-12 | AHU-377 HeMicalciuM Salt
1369773-39-6
|
US $14.00 / Kg/Bag | 1Kg/Bag | 98% | Weekly supply of 1000KG | Wuhan Dujiang Industrial Co., Ltd. |
-
- Sacubitril hemicalcium salt
1369773-39-6
- US $33.00-58.00 / mg
- 99.93%
- TargetMol Chemicals Inc.
-
- Ahu-377 Hemicalcium Salt
1369773-39-6
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- AHU-377 HeMicalciuM Salt
1369773-39-6
- US $14.00 / Kg/Bag
- 98%
- Wuhan Dujiang Industrial Co., Ltd.
1369773-39-6(AHU-377 (heMicalciuM salt))Related Search:
AHU377-d4
Sacubitril-(2R,4R)-Isomer
AHU-377
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride
LCZ696
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
LCZ696 interMediate
(2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
(2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid
(S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one
Sacubitril Impurity 72
(2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid
((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester
2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-
Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate
1of4
AHU-377 (heMicalciuM salt)
(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
(2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1)
AHU-377 hemicalcium salt (2:1)
Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate)
Sacubitril Hemicalcium salt
(αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
[1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
(alphaR, gammaS) -gamma-[(3- carbonyl, -1-, oxo propyl), amino]-alpha-, biphenyl, -4-, ethyl valerate, calcium salt
LCZ696(valsartan + sacubitril) impurity 1
Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
(alphar
1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
gammas)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1
LCZ696-1
monocalciummono(4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy- 4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate)
Calcium4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (AHU-377 hemicalcium salt)
AHU377 Calcium Salt
AHU-377 Hemicalcium
LCZ696 Impurity 534-06
(αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoicacid4-ethylestercalciumsal
LCZ696 intermediates，AHU-377 (heMicalciuM salt)
(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-m...
SACUBITRIL-13C4 CALCIUM
Sacubitril-d5 Calcium Salt
Sacubitril 13C4 CalciumQ: What is
Sacubitril 13C4 Calcium Q: What is the CAS Number of
Sacubitril 13C4 Calcium
(αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
Sacubitril Calcium
Sacubitril calcium salt
Sacubitril hemicalcium
LCZ-696 Impurity 29 calcium salt
Ethyl (2R,4S)-5-(Biphenyl-4-yl)-4-(amino)-5-(3-carboxypropionyl)amino]-2-methylpentanoate, calcium salt
Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Calcium 4-((2S,4R)-1-(biphenyl-4-yl) -5-ethoxy-4-methyl-5-oxopentan-2-ylamino)-4-oxobutanoate
Sacubitril calcium salt（AHU-377 ）
Sacubitril Calcium Salt CRS
Sacubitrol calcium salt
(2R, 4S) -5- (biphenyl-4-yl) -4- (amino) -5- (3-carboxy-propionylamino-2-methyl-ventrate ethyl ester calcium salt
Sacubitrial Calcium
LCZ 696 hemicalcium salt
LCZ696 hemicalcium salt
Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
Sabatrol calcium
(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
1369773-39-6
2C24H29NO5Ca
C48H56CaN2O10
Intermediates
LCZ 696
Pharmaceutical Intermediates
lcz696
1369773-39-6