Mirodenafil Dihydrochloride
- CAS No.
- 862189-96-6
- Chemical Name:
- Mirodenafil Dihydrochloride
- Synonyms
- CS-1262;SK 3530;mirodenafil HCl;SK-3530 dihydrochloride;Mirodenafil hydrocloride;Mirodenafil Dihydrochloride;Mirodenafil (hydrochloride);Mirodenafil dihydrochloride, >=98%;Mirodenafil dihydrochloride - Bio-X ?;Mirodenafil dihydrochloride, 10 mM in DMSO
- CBNumber:
- CB72512298
- Molecular Formula:
- C26H37N5O5S
- Molecular Weight:
- 531.66748
- MDL Number:
- MFCD28139019
- MOL File:
- 862189-96-6.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 10 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
| FDA UNII | NL7L8TWT8Y |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Mirodenafil Dihydrochloride price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29045 | Mirodenafil (hydrochloride) | 862189-96-6 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 29045 | Mirodenafil (hydrochloride) | 862189-96-6 | 10mg | $903 | 2024-03-01 | Buy |
| Cayman Chemical | 29045 | Mirodenafil (hydrochloride) | 862189-96-6 | 5mg | $481 | 2024-03-01 | Buy |
| TRC | M364950 | MirodenafilDihydrochloride | 862189-96-6 | 1mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-3125 | Mirodenafildihydrochloride 99.79% | 862189-96-6 | 5mg | $420 | 2021-12-16 | Buy |
Mirodenafil Dihydrochloride Chemical Properties,Uses,Production
Uses
Mirodenafil, a phosphodiesterase 5 inhibitor reported to be effective in the treatment of erectile dysfunction, is metabolized by cytochrome P 450 (CYP) 3A4 to the active metabolite N-dehydroxyethyl mirodenafil. Mirodenafil may have drug-drug interactions with ketoconazole and/or rifampicin.
Biological Activity
Mirodenafil (SK3530) is an orally active, highly potent and selective phosphodiesterase-5 (PDE5) inhibitor (IC50 = 338 pM). with therapeutic efficacy in various ED models in vivo. Comparing to sildenafil, mirodenafil shows ~10-times higher PDE5 selectivity in vitro and remains longer in the plasma and corpus cavernosum following oral dosing at 40 mg/kg in rats in vivo.
in vivo
Mirodenafil dihydrochloride (4 mg/kg, IP, daily for 4 weeks) enhances the cognitive-behavioral performance in transgenic AD mice[2].
Mirodenafil dihydrochloride (0-10 mg/kg, Orally, daily for 3 weeks) ameliorates dermal fibrosis in a BLM-induced SSc mouse model by inhibiting the TGF-β signaling pathway, thereby suppressing the expression of collagen and profibrotic genes[3].
| Animal Model: | APP-C105 transgenic mice (13-month-old, male, n=6)[2] |
| Dosage: | 4 mg/kg |
| Administration: | IP, daily for 4 weeks |
| Result: | Improved cognitive function in the APP-C105 AD mice. |
| Animal Model: | Male BALB/c mice (8 weeks old, four groups, n=10/group)[3] |
| Dosage: | 0, 5 or 10?mg/kg |
| Administration: | Orally, daily for 3 weeks |
| Result: | Ameliorated dermal fibrosis and downregulated the protein levels of fibrosis markers including COL1A1 and α-SMA in the BLM-induced SSc mouse model. Significantly decreased dermal thickness and collagen content. |
IC 50
PDE5
Mirodenafil Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 904 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9642 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38659 | 58 | |
| CONTIDE BIOTECH CO.,LTD | +852-7026-8763 +85253358525 | China | 481 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | thtang@dycnchem.com | China | 53900 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from Mirodenafil Dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | Mirodenafil dihydrochloride
862189-96-6
|
US $30.00-81.00 / mg | 99.64% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-01 | Mirodenafil Dihydrochloride
862189-96-6
|
US $10.00-0.00 / g | 10g | 98%+ | 100kgs | Wuhan Nutra Biotechnology Co.,Ltd | |
 |
2019-07-31 | Mirodenafil Dihydrochloride
862189-96-6
|
US $1.00 / g | 1g | 99% | 50 Kilogram/Kilograms per Month | Cangzhou Wanyou New Material Technology Co.,Ltd |
-
- Mirodenafil dihydrochloride
862189-96-6
- US $30.00-81.00 / mg
- 99.64%
- TargetMol Chemicals Inc.
-
- Mirodenafil Dihydrochloride
862189-96-6
- US $10.00-0.00 / g
- 98%+
- Wuhan Nutra Biotechnology Co.,Ltd
-
- Mirodenafil Dihydrochloride
862189-96-6
- US $1.00 / g
- 99%
- Cangzhou Wanyou New Material Technology Co.,Ltd