Tegaserod maleate
- CAS No.
- 189188-57-6
- Chemical Name:
- Tegaserod maleate
- Synonyms
- ZELMAC;HTF 919;ZelnorM;Tegibs 6;Toromifene;SDZ-HTF-919;TegaserodMalate;TegastrodMaleate;TEGASEROD MALEATE;Tegaserol Maleate
- CBNumber:
- CB7225422
- Molecular Formula:
- C20H27N5O5
- Molecular Weight:
- 417.46
- MDL Number:
- MFCD04116201
- MOL File:
- 189188-57-6.mol
- MSDS File:
- SDS
| Melting point | 180-183°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Sparingly) |
| form | powder |
| color | white to beige |
| CAS DataBase Reference | 189188-57-6(CAS DataBase Reference) |
| FDA UNII | E5XNT3RF5A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H400-H410-H317 |
| Precautionary statements | P273-P391-P501-P273-P391-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
Tegaserod maleate price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1504 | Tegaserod maleate ≥98% (HPLC) | 189188-57-6 | 10MG | $120 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1504 | Tegaserod maleate ≥98% (HPLC) | 189188-57-6 | 50MG | $490 | 2024-03-01 | Buy |
| Cayman Chemical | 14692 | Tegaserod (maleate) ≥98% | 189188-57-6 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 14692 | Tegaserod (maleate) ≥98% | 189188-57-6 | 10mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 14692 | Tegaserod (maleate) ≥98% | 189188-57-6 | 25mg | $217 | 2024-03-01 | Buy |
Tegaserod maleate Chemical Properties,Uses,Production
Description
Tegaserod maleate was launched as a new oral treatment of constipationpredominant or diarrhea-predominant irritable bowel syndrome. It can be prepared by condensation of the 5-methoxy-3-formylindole with the appropriate aminoguanidine. Tegaserod is a selective partial agonist of the excitatory 5-HT4 receptor (K1 = 18 nM in human caudate membranes) and was designed from the endogenous full agonist, seretonin. In the model of potentiation of the electrically stimulated contraction of longitudinal muscle of guinea pig ileum, Tegaserod exhibited a low-efficacy agonistic activity compared with serotonin. However, it appeared more potent in several studies on intestinal mucosal tissue from various species including man. A lack of effect on the QTc interval was shown in rabbits then confirmed during clinical studies. Tegaserod is also clinically developed for the treatment of other functional GI disorders such as functional dyspepsia and gastroesophageal reflux disease (GERD).
Chemical Properties
White Powder
Originator
Novartis (Switzerland)
Uses
Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective serotonin 5HT4-receptor partial agonist.
Uses
Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.
brand name
Zelnorm (Novartis);Zelmac.
Biochem/physiol Actions
It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.
storage
+4°C
Tegaserod maleate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29885 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32079 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
View Lastest Price from Tegaserod maleate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-14 | Tegaserod maleate
189188-57-6
|
US $39.00-122.00 / mg | 99.06% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-07-28 | Tegaserod maleate
189188-57-6
|
US $10.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.，LTD | |
 |
2022-02-25 | Tegaserod maleate
189188-57-6
|
US $88.00 / KG | 1KG | 99% | 1 ton | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- Tegaserod maleate
189188-57-6
- US $39.00-122.00 / mg
- 99.06%
- TargetMol Chemicals Inc.
-
- Tegaserod maleate
189188-57-6
- US $10.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.，LTD
-
- Tegaserod maleate
189188-57-6
- US $88.00 / KG
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
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