Tak-715
- CAS No.
- 303162-79-0
- Chemical Name:
- Tak-715
- Synonyms
- Tak-715;CS-1566;TAK-715; TAK715;TAK-715, 10 mM in DMSO;TAK 715, p38 MAPK inhibitor;Tak-715 ISO 9001：2015 REACH;N-(4-(2-Ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide;N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide;N-(4-(2-Ethyl-4-(3-methylphenyl)-thiazol-5-yl)pyridin-2-yl)benzamide;N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide
- CBNumber:
- CB71017172
- Molecular Formula:
- C24H21N3OS
- Molecular Weight:
- 399.51
- MDL Number:
- MFCD17012805
- MOL File:
- 303162-79-0.mol
- MSDS File:
- SDS
| storage temp. | Sealed in dry,2-8°C |
|---|---|
| solubility | DMSO: >15mg/mL |
| form | powder |
| color | faint yellow to dark yellow |
| FDA UNII | WE92U03C5Z |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Tak-715 price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0360 | TAK-715 ≥98% (HPLC) | 303162-79-0 | 5mg | $192 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0360 | TAK-715 ≥98% (HPLC) | 303162-79-0 | 25mg | $674 | 2022-05-15 | Buy |
| Cayman Chemical | 26170 | TAK-715 | 303162-79-0 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 26170 | TAK-715 | 303162-79-0 | 50mg | $632 | 2024-03-01 | Buy |
| Cayman Chemical | 26170 | TAK-715 | 303162-79-0 | 10mg | $152 | 2024-03-01 | Buy |
Tak-715 Chemical Properties,Uses,Production
Uses
TAK 715 is a p38 MAPK inhibitor for p38α and p38β but not for p38γ and p38δ.
Definition
ChEBI: N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide is a member of benzamides.
Biological Activity
tak-715 is a selective inhibitor of p38 mapk with ic50 value of 7.1 nm [1].p38 mitogen-activated protein (map) kinases (p38 mapks) are a class of mitogen-activated protein kinases and play an important role in controlling cellular responses to cytokines and stress. four p38 mapks contain members, p38-α (mapk14), p38-β (mapk11), p38-γ (mapk12/erk6), and p38-δ (mapk13/sapk4), have been identified. abnormal expression of p38 mapks are correlated with a variety of chronic inflammatory diseases and their inhibitors are regarded as promising targets in clinical [1] [2].tak-715 is a potent p38 mapk inhibitor and has a different selectivity with the reported p38 mapk inhibitor vx-745. when tested with human monocytic thp-1 cells, administration of tak-715 exhibited inhibition on p38mapkα with ic50 value of 7.1 nm [1]. in hek293t, u2os, and f9 cells, tak-715 was used to inhibit p38 mapk activity and concluded that p38 mapk had no function in wnt/β-catenin signaling pathway [2].in adjuvant-induced rheumatoid arthritis rat model, administration of tak-715 at dose of 10 mg/kg significantly decreased lps-induced stimulated release of tnf-α (87.6%) by inhibiting p38 mapk activity [1].
storage
+4°C
References
[1]. miwatashi, s., et al., novel inhibitor of p38 map kinase as an anti-tnf-alpha drug: discovery of n-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (tak-715) as a potent and orally active anti-rheumatoid arthritis agent. j med chem, 2005. 48(19): p. 5966-79.
[2]. verkaar, f., et al., inhibition of wnt/beta-catenin signaling by p38 map kinase inhibitors is explained by cross-reactivity with casein kinase idelta/varepsilon. chem biol, 2011. 18(4): p. 485-94.
Tak-715 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29809 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 |
View Lastest Price from Tak-715 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | TAK-715
303162-79-0
|
US $34.00-79.00 / mg | 99.69% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-17 | Tak-715
303162-79-0
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-13 | Tak-715
303162-79-0
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |