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ChemicalBook >> CAS DataBase List >>T-690

T-690

CAS No.
2597958-02-4
Chemical Name:
T-690
Synonyms
T-690;Glucosylceramide synthase-IN-2;N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-4-pyridazinecarboxamide;4-Pyridazinecarboxamide, 2,3-dihydro-N-[4-(1-hydroxy-1-methylethyl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-
CBNumber:
CB611074289
Molecular Formula:
C22H20F3N3O4
Molecular Weight:
447.41
MDL Number:
MOL File:
2597958-02-4.mol
Last updated:2025-04-27 16:16:43

T-690 Properties

Density 1.32±0.1 g/cm3(Predicted)
storage temp. 4°C, away from moisture and light
pka 12.39±0.70(Predicted)
form Solid
color Light yellow to yellow

T-690 Chemical Properties,Uses,Production

Description

GCS Inhibitor T-690 is a novel brain-penetrant GCS inhibitor with a lower toxicological risk, which reduced glucosylceramide in a dose-dependent manner in the plasma and cortex of mice.

Uses

Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research[1].

in vivo

Glucosylceramide synthase-IN-2 (compound T-690; po; 30, 100, 300 mg/kg)?reduces GlcCer concentrations in the plasma and cerebral cortex in a dose-dependent manner in C57BL/6J mice[1].
Glucosylceramide synthase-IN-2 (po; 5 mg/kg) has a Cmax of 416 ng/mL. Glucosylceramide synthase-IN-2 shows good oral exposure (BA = 31%)[1].
Glucosylceramide synthase-IN-2 reveals good brain exposure (Cu,brain = 0.21 μM at 30 mg/kg dosing, 1 h)[1].

References

[1] Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290 DOI:10.1021/acs.jmedchem.1c02078

T-690 Preparation Products And Raw materials

Raw materials

Preparation Products

T-690 Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
DC Chemicals 021-58447131 13564518121 doncunbiosci@gmail.com China 9517 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 998 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24847 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 7328 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29998 58

View Lastest Price from T-690 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Glucosylceramide synthase-IN-2 pictures 2025-04-27 Glucosylceramide synthase-IN-2
2597958-02-4
 US $2110.00-3150.00 / mg 10g TargetMol Chemicals Inc.
T-690 Glucosylceramide synthase-IN-2 4-Pyridazinecarboxamide, 2,3-dihydro-N-[4-(1-hydroxy-1-methylethyl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]- N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-4-pyridazinecarboxamide 2597958-02-4