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N,N-Bis(2-hydroxyethyl)glycin

Bicine Struktur
150-25-4
CAS-Nr.
150-25-4
Bezeichnung:
N,N-Bis(2-hydroxyethyl)glycin
Englisch Name:
Bicine
Synonyma:
BICINE BUFFER;N,N-BIS(2-HYDROXYETHYL)GLYCINE;BIClNE;BICINE;Biobuffer;BICINE, 99+%;Fe-3-Specific;Bicine, ULTROL;BICINE BIOXTRA;DIETHYLOLGLYCINE
CBNumber:
CB8470568
Summenformel:
C6H13NO4
Molgewicht:
163.17
MOL-Datei:
150-25-4.mol

N,N-Bis(2-hydroxyethyl)glycin Eigenschaften

Schmelzpunkt:
190 °C (dec.)(lit.)
Siedepunkt:
290.25°C (rough estimate)
Dichte
1.05 g/mL at 20 °C
Dampfdruck
0.002-0.007Pa at 20-25℃
Brechungsindex
1.4240 (estimate)
storage temp. 
room temp
L?slichkeit
H2O: 1 M at 20 °C, clear, colorless
Aggregatzustand
Powder
Farbe
White
S?ure-Base-Indikators(pH-Indikatoren)
7.6 - 9.0
PH
4.0-5.5 (25℃, 1M in H2O)
pka
8.3(at 25℃)
Wasserl?slichkeit
soluble
maximale Wellenl?nge (λmax)
λ: 260 nm Amax: 0.070
λ: 280 nm Amax: 0.040
Merck 
14,1201
BRN 
1769362
LogP
2.3 at 20℃ and pH7
Oberfl?chenspannung
72.2mN/m at 1g/L and 20℃
CAS Datenbank
150-25-4(CAS DataBase Reference)
EPA chemische Informationen
Bicine (150-25-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22-36/37/38
S-S?tze: 24/25-36-26
WGK Germany  3
RTECS-Nr. MB9700000
3-10
TSCA  Yes
HS Code  29225000
Toxizit?t mouse,LD50,intraperitoneal,1540mg/kg (1540mg/kg),KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)",Revue d'Epidemiologie, Medecine Sociale et Sante Publique. Vol. 10, Pg. 391, 1962.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H332 Gesundheitssch?dlich bei Einatmen. Akute Toxizit?t inhalativ Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P271, P304+P340, P312
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

N,N-Bis(2-hydroxyethyl)glycin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Bicine is an amino acid that results from amine degradation due to the presence of oxygen and/or sulfur dioxide. The amine solvents that undergo this degradation are MDEA, DEA, TEA, and mixed amine solvents containing any of these amines. As a zwitterionic amino acid buffer agent, bicine is active in the pH 7.6-9.0 range (pKa of 8.26 at 25°C). Bicine is a recommended buffer for low-temperature biochemical work. It is used for the preparation of stable substrate solution for serum guanase determination. It can be used as a nitrogenous strength enhancer to regulate cement hydration and improve cement properties. Studies have found that bicine significantly changes the morphology of portlandite crystals from a parallel-stacked lamellar shape to a distorted one and also decreases the pore size of the hardened cement paste at an early age[1]. In particular, bicine could promote the rapid formation of β-sheet-rich amyloid-β fibrils[2].

Chemische Eigenschaften

Bicine is a white/clear crystalline powder that is somewhat soluble in water. It contains an amino group, carboxyl group, and two hydroxyl units in its structure, making it highly polar. It is often used as a biological buffer and chelating agent.

Verwenden

A zwitterionic amino acid buffer agent used for low temperature work. The use of bicine in a thin layer ion exchange chromatography method for protein resolution has been published. Bicine has been utilized in peptide and protein crystallization. A kinetic study of a quaternary transition-state analogue complex of creatine kinase used bicine in the reaction buffer. A multiphasic buffer system for SDS-PAGE of proteins and peptides that incorporates bicine has been described.

l?uterung methode

Dissolve bicine in a small volume of hot water and precipitate it with EtOH, twice. Repeat once more but treat the aqueous solution with charcoal Purification of Biochemicals — Amino Acids and Peptides and filter before adding EtOH. Also crystallise it from concentrated aqueous solutions. [Torn & Kolthoff J Am Chem Soc 77 2061 1955, Chaberek et al. J Am Chem Soc 75 2185 1953, Beilstein 4 IV 2390.]

N,N-Bis(2-hydroxyethyl)glycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N,N-Bis(2-hydroxyethyl)glycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 474)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Suzhou Genemill Biotechnology Co.,Ltd
+8615862502491
aimeegao@genemill.com China 39 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18751 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075
jack.li@time-chemicals.com China 1803 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9080 55
AB PharmaTech,LLC
323-480-4688
sales@acrospharmatech.com United States 989 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58

150-25-4(N,N-Bis(2-hydroxyethyl)glycin)Verwandte Suche:


  • n,n-dihydroxyethyl-glycin
  • Bicine N,N-Bis(2-hydroxyethyl)glycine Diethanolglycine
  • N,N-DI(2-HYDROXYETHYL)GLYCINE
  • N N-DI(HYDROXYETHYL)-B-AMINOACETIC ACID
  • BICINE[N,N-Di(2-hydroxyethyl)glycine]
  • BICIN (N,N-Bis-(2-hydroxyethyl)-glycin)
  • N,N-Di(2-hydroxyethyl)glycine 
  • Bicine, for analysis, 99+% 100GR
  • Bicine, for biocheMistry, 99+% 100GR
  • [BIS-(2-HYDROXY-ETHYL)-AMINO]-ACETIC ACID (BICINE)
  • Bicine SynonyMs Diethylolglycine
  • PEG Grid Screening Solution 24/Fluka kit no 36436
  • N,N--Di(2-hydroxyethyl)glycine
  • BIClNE
  • MALACHITE GREEN OXALATE HIGH PURITY GR
  • DI(HYDROXYETHYL)GLYCINE
  • DIETHYLOLGLYCINE
  • DIETHANOLGLYCINE
  • [BIS-(2-HYDROXY-ETHYL)-AMINO]-ACETIC ACID
  • BICINE
  • N,N-DIHYDROXYETHYL GLYCINE
  • BICINE buffer Solution
  • Bicine, Molecular Biology Grade N,N-Bis(2-hydroxyethyl)glycine, Molecular Biology Grade
  • Bicine, ULTROL Grade
  • BICINE BUFFER SOLUTION 1M IN WATER*
  • BICINE, 99+%
  • BICINE SIGMAULTRA
  • BICINE, MOLECULAR BIOLOGY GRADE
  • Bicine, for analysis, 99+%
  • BICINE ULTRAPURE
  • N,N-BIS(2-HYDROXYETHYL)GLYCINE(BICINE)
  • N,N-Bis(2-hydroxyethyl)glycine >98%
  • N,N-Di(2-hydroxyethyl)glycine [Good's buffer component for biological research]
  • 2-(Bis(2-hydroxyethyl)amino)acetic acid
  • N,N-dihydroxyethyl
  • Bis(2-hydroxyethyl)glycine
  • Glycine, N,N-bis(2-hydroxyethyl)-
  • BICINE,BIOLOGICALBUFFER
  • GLYCINE,N,N-DIHYDROXYETHYL-
  • Fe-3-Specific
  • N,N-Bis(2-hydroxyethyl)aminoacetic acid
  • N,N-Bis(b-hydroxyethyl)glycine
  • Bicine,99+%,for analysis
  • BICINE, 99+%, FOR BIOCHEMISTRY
  • Bicine, for analysis
  • Bicine, for biochemistry
  • Bicine, for biochemistry, 99+%
  • LABOTEST-BB LT00452695
  • BicineUltra pure, ≥ 99% (Titration: dried basis)
  • Bicine, ULTROL
  • BICINE 30% PEG 600 solution
  • n,n-bis(2-hydroxyethyl)-glycin
  • BICINE BIOXTRA
  • N-bis-(2-Hydroxyethyl)glycine
  • Bicine, ULTROL Grade - CAS 150-25-4 - Calbiochem
  • 2-(dihydroxyamino)butanoic acid
  • Bicine for Molecular Biology
  • N,N-Di(2-hydroxyethyl)glycine [Good's buffer component for biological research]>
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