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ChemicalBook >> CAS DataBase List >>2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)-

2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)-

CAS No.
2313528-04-8
Chemical Name:
2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)-
Synonyms
hnRNPK-IN-1;hnRNPK IN 1,hnRNPKIN1;2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)-
CBNumber:
CB58843929
Molecular Formula:
C23H21N3O5
Molecular Weight:
419.43
MDL Number:
MFCD34179487
MOL File:
2313528-04-8.mol
Last updated:2024-10-28 16:48:35

2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)- Properties

Boiling point 673.6±55.0 °C(Predicted)
Density 1.325±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 5 mg/mL (11.92 mM; ultrasonic and warming and heat to 80°C)
pka 3.81±0.61(Predicted)
form Solid
color Brown to orange

2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)- Chemical Properties,Uses,Production

Biological Activity

hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with Kd values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities[1]. hnRNPK-IN-1 (Compound 25; 1.25-5 μM; 24 hours) treatment induces Hela cells apoptosis could be due to its repression of cmyc transcription[1].hnRNPK-IN-1 (1.25-5 μM; 48 hours) treatment down-regulates c-myc gene transcription and expression in Hela cells in a dose-dependent manner[1].hnRNPK-IN-1 shows a selective anti-proliferative effect on human cancer cell lines (Siha, A549, Hela, U2OS, A375, HuH7 and HEK293 cells) with IC50 values ranged from 1.36 to 3.59 μM[1].hnRNPK-IN-1 could selectively bind to hnRNP K without significant interaction with c-myc promoter DNA. The binding of hnRNPK-IN-1 to hnRNP K could disrupt the interaction between hnRNP K and c-myc promoter DNA in vitro and in cells[1]. hnRNPK-IN-1 (Compound 25; 6.7-20 mg/kg; i.p.; once a day; for three weeks) exhibits good tumor growth inhibition in a Hela xenograft tumor model[1].

References

[1]. Bing Shu, et al. Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription. Bioorg Chem. 2019 Apr;85:1-17.

2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)- Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19881 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19699 58

View Lastest Price from 2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
hnRNPK-IN-1 pictures 2024-10-28 hnRNPK-IN-1
2313528-04-8
 US $2500.00-1980.00 / mg 10g TargetMol Chemicals Inc.
  • hnRNPK-IN-1 pictures
  • hnRNPK-IN-1
    2313528-04-8
  • US $2500.00-1980.00 / mg
  • TargetMol Chemicals Inc.
2-Propen-1-one, 1-(4-methoxyphenyl)-3-[4-(4-morpholinyl)-6-nitro-2-quinolinyl]-, (2E)- hnRNPK-IN-1 hnRNPK IN 1,hnRNPKIN1 2313528-04-8