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9H-PYRIDO[3,4-B]INDOLE

9H-PYRIDO[3,4-B]INDOLE structure

CAS No.: 244-63-3

Chemical Name:: 9H-PYRIDO[3,4-B]INDOLE

Synonyms: NORHARMAN;NORHARMANE;β-carboline;BETA-CARBOLINE;B-CARBOLINE;Pyridoindole;NSC 8441;NSC 84417;9H-BETA-CA;CARBAZOLINE

CBNumber:: CB5431618

Molecular Formula:: C11H8N2

Molecular Weight:: 168.19

MDL Number:: MFCD00004956

MOL File:: 244-63-3.mol

MSDS File:: SDS

Last updated:2024-10-31 18:15:48

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9H-PYRIDO[3,4-B]INDOLE Properties

Melting point	199-201 °C
Boiling point	287.13°C (rough estimate)
Density	1.1722 (rough estimate)
refractive index	1.5200 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	crystalline
pka	15.44±0.30(Predicted)
color	light yellow
Water Solubility	2693g/L(17 ºC)
InChIKey	AIFRHYZBTHREPW-UHFFFAOYSA-N
LogP	3.170
CAS DataBase Reference	244-63-3(CAS DataBase Reference)
FDA UNII	94HMA1I78O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36/37/39-26-22
RIDADR	3261
WGK Germany	3
RTECS	UU9350000
HS Code	29339900
Toxicity	dnd-hmn:hla 50 mmol/L MUREAV 89,95,81

9H-PYRIDO[3,4-B]INDOLE price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N6252	Norharmane crystalline	244-63-3	100mg	$47.1	2024-03-01	Buy
Sigma-Aldrich	N6252	Norharmane crystalline	244-63-3	1g	$240	2024-03-01	Buy
TCI Chemical	P1121	9H-Pyrido[3,4-b]indole >98.0%(GC)(T)	244-63-3	100mg	$35	2024-03-01	Buy
Cayman Chemical	20043	Norharmane ≥98%	244-63-3	250mg	$37	2024-03-01	Buy
Cayman Chemical	20043	Norharmane ≥98%	244-63-3	500mg	$68	2024-03-01	Buy

Product number	Packaging	Price	Buy
N6252	100mg	$47.1	Buy
N6252	1g	$240	Buy
P1121	100mg	$35	Buy
20043	250mg	$37	Buy
20043	500mg	$68	Buy

9H-PYRIDO[3,4-B]INDOLE Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

Uses

The compund has cytotoxic effects.

Definition

ChEBI: The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 2962, 1950 DOI: 10.1021/ja01163a041
Tetrahedron, 49, p. 49, 1993 DOI: 10.1016/S0040-4020(01)80505-6

Hazard

Toxic; nervous system effects.

Biological Activity

norharmane acts as a co-mutagen. norharmane is a natural β-carboline first isolated from plants of the zygophyllaceae family. it is a heterocyclic amine (hca) that may also be found in fried meats, tobacco smoke, and coffee. harman and norharmane are aminocarbolines known as “co-mutagens” because they do not show mutagenicity to salmonella serovar typhimurium [1][2][3].norharmane acts as a co-mutagen. norharmane is widely distributed in our environment. it was not mutagenic to salmonella typhimurium ta98 and ta100 either with or without s9 mix, but became mutagenic to s.typhimurium ta98 with s9 mix when non-mutagenic aromatic amines like aniline or o- or m-toluidine are added. also, norharmane and aromatic amines induced the formation of dna adduct in s.typhimurium ta98 [3].harman and norharmane with concentrations of 0.275 um and 0.9 um respectively might inhibited mao-a and mao-b. in adult male rats, a novel cocktail of cigarette smoke constituents, containing five minor alkaloids (nornicotine, cotinine, myosmine, anatabine, and anabasine), two β-carbolines (harman and norharmane), and acetaldehyde, did not significantly enhance nicotine self-administration [2].

Biochem/physiol Actions

Inhibitor of indoleamine 2,3-dioxygenase (IDO).

Safety Profile

Poison by intravenous route.Experimental reproductive effects. Human mutation datareported. When heated to decomposition it emits toxicfumes of NOx.

References

[1]. jamali ma, zhang y, teng h, et al. inhibitory effect of rosa rugosa tea extract on the formation of heterocyclic amines in meat patties at different temperatures. molecules. 2016 jan 30;21(2):173.
[2]. smith tt, schaff mb, rupprecht le, et al. effects of mao inhibition and a combination of minor alkaloids, β-carbolines, and acetaldehyde on nicotine self-administration in adult male rats. drug alcohol depend. 2015 oct 1;155:243-52.
[3]. mori m1, totsuka y, fukutome k, et al. formation of dna adducts by the co-mutagen norharman with aromatic amines. carcinogenesis. 1996 jul;17(7):1499-503.

9H-PYRIDO[3,4-B]INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

9-Methyl-9H-beta-carboline 9-(4Nitrophenyl)-9H-pyrido[3,4-b]indole

9H-PYRIDO[3,4-B]INDOLE Suppliers

Global( 221)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29886	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	19943	58
BAYNOE CHEM CO.,LTD	+86-21-34783353 +8615000719740	baynoe@baynoe.com	CHINA	934	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
HaBo Hong Kong Co., Limited.	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
BAYNOE CHEM CO.,LTD	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 9H-PYRIDO[3,4-B]INDOLE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-10-31	Norharmane 244-63-3	US $30.00 / mL		98.76%	10g	TargetMol Chemicals Inc.
2022-10-15	9H-PYRIDO[3,4-B]INDOLE 244-63-3	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	9H-PYRIDO[3,4-B]INDOLE 244-63-3	US $1.00 / KG	1KG	99%	1ton	Career Henan Chemical Co

Norharmane
244-63-3
US $30.00 / mL
98.76%
TargetMol Chemicals Inc.

9H-PYRIDO[3,4-B]INDOLE
244-63-3
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

9H-PYRIDO[3,4-B]INDOLE
244-63-3
US $1.00 / KG
99%
Career Henan Chemical Co

9H-PYRIDO[3,4-B]INDOLE Spectrum

9H-PYRIDO[3,4-B]INDOLE(244-63-3)MS 9H-PYRIDO[3,4-B]INDOLE(244-63-3)¹HNMR 9H-PYRIDO[3,4-B]INDOLE(244-63-3)IR1 9H-PYRIDO[3,4-B]INDOLE(244-63-3)IR2 9H-PYRIDO[3,4-B]INDOLE(244-63-3)Raman

244-63-3(9H-PYRIDO[3,4-B]INDOLE)Related Search:

SEMPERVIRINE NITRATE HARMANE ( 1-METHYL-9H-PYRIDO[3,4-B]INDOLE),Aribine~1-Methyl-9H-pyrido[3,4-b]indole n-methyl-9h-pyrido(3,4-b)indole-3-carboxamid 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl- 1-Methyl-9H-pyrido[3,4-b]indole.HCl,1-methyl-9H-pyrido[3,4-b]indole hydrochloride

SERPENTINE HYDROGEN TARTRATE HARMINE HYDROCHLORIDE HARMOL HYDROCHLORIDE 3,4-dihydro-7-methoxy-1-methyl-9-pyrido(3,4-b)indol 3-AMINO-1,4-DIMETHYL-5H-PYRIDO[4,3-B]INDOLE, ACETATE

2-AMINO-9H-PYRIDO[2,3-B]INDOLE 2-amino-3-methyl-1h-pyrido(2,3-b)indol 3-AMINO-1-METHYL-5H-PYRIDO[4,3-B]INDOLE Chloropretadalafil 6-METHOXY-1,2,3,4-TETRAHYDRO-9H-PYRIDO-( 3,4B)INDOLE (MAO,2,3,4,9-tetrahydro-6-methoxy-1h-pyrido(3,4-b)indol

1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2-methyl-5-(phenylmethyl)-,5-Benzyl-1,3,4,5-tetrahydro-2-methyl-2H-pyrido[4,3-b]indole (1R,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-Methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate 1H-Pyrido[3,4-b]indole,2,3,4,9-tetrahydro

1of4

CARBAZOLINE 2,9-DIAZAFLUORENE 9H-BETA-CARBOLINE 9H-PYRIDO[3,4-B]INDOLE PYRIDO(3,4-B)INDOLE NORHARMANE FREE BASE NORHARMAN 98% NSC 8441 NSC 84417 Norharman,98% NorharMan, 98% 500MG beta-Carboline Norharman Norharman, free base 2-azacarbazole 9H-β-Carboline 9H-PYRIDO[3,4-B]INDOLE USP/EP/BP 9H-Pyrido[3,4-b]indole> 9H-BETA-CA B-CARBOLINE BETA-CARBOLINE Pyridoindole NORHARMAN NORHARMANE β-carboline 9H-pyridine [3,4-b] indole 244-63-3 244-64-3 C6H4NHC6H10 Heterocycles Mutagenesis Research Chemicals Miscellaneous Natural Products

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9H-PYRIDO[3,4-B]INDOLE

9H-PYRIDO[3,4-B]INDOLE Properties

SAFETY

Risk and Safety Statements

9H-PYRIDO[3,4-B]INDOLE price More Price(46)

9H-PYRIDO[3,4-B]INDOLE Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Definition

Synthesis Reference(s)

Hazard

Biological Activity

Biochem/physiol Actions

Safety Profile

References

9H-PYRIDO[3,4-B]INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

9H-PYRIDO[3,4-B]INDOLE Suppliers

View Lastest Price from 9H-PYRIDO[3,4-B]INDOLE manufacturers

9H-PYRIDO[3,4-B]INDOLE Spectrum

244-63-3(9H-PYRIDO[3,4-B]INDOLE)Related Search: