M348
- CAS No.
- 899713-86-1
- Chemical Name:
- M348
- Synonyms
- M348;ML348;CS-2370;GNF-Pf-1127;ML-348 (ML348);ML 348;GNF-PF-1127;ML348, 10 mM in DMSO;APT1 Inhibitor II, Cpd21;alpha-synuclein 1-95, human;ML 348,Phospholipase,ML348,ML-348,inhibit,Inhibitor
- CBNumber:
- CB53147505
- Molecular Formula:
- C18H17ClF3N3O3
- Molecular Weight:
- 415.79
- MDL Number:
- MFCD05123530
- MOL File:
- 899713-86-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
M348 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1901 | ML348 ≥98% (HPLC) | 899713-86-1 | 5MG | $105 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1901 | ML348 ≥98% (HPLC) | 899713-86-1 | 25MG | $424 | 2024-03-01 | Buy |
| Cayman Chemical | 18523 | ML348 ≥98% | 899713-86-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18523 | ML348 ≥98% | 899713-86-1 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 18523 | ML348 ≥98% | 899713-86-1 | 10mg | $184 | 2024-03-01 | Buy |
M348 Chemical Properties,Uses,Production
Uses
ML348 is a reversible LYPLA1 inhibitor. It is 14-fold selective for LYPLA1 over LYPLA2 and demonstrates little activity against a panel of more than 20 other serine hydrolases.
Biochem/physiol Actions
ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.
in vivo
ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice[1].
| Animal Model: | C57BL6 male mice (3-4 months)[1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; 3 hours |
| Result: | Potent and selective inhibited LYPLA1 enzymes in heart, kidney and lung in vivo. |
storage
Store at +4°C
M348 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38662 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
