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ChemicalBook >> CAS DataBase List >>Vipadenant

Vipadenant

CAS No.
442908-10-3
Chemical Name:
Vipadenant
Synonyms
V 2006;CS-2294;BIIB 014;CEB 4520;VER 11135;Vipadenant;VER-ADO 49;VER-A 00-11;VER-A 00049;BIIB-014, CEB-4520
CBNumber:
CB52627600
Molecular Formula:
C16H15N7O
Molecular Weight:
321.34
MDL Number:
MFCD12024697
MOL File:
442908-10-3.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24

Vipadenant Properties

Melting point 245.3-246.1 °C
Boiling point 668.5±65.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:37.0(Max Conc. mg/mL);115.14(Max Conc. mM)
form A crystalline solid
pka 4.27±0.30(Predicted)
color Light yellow to yellow
FDA UNII LDR3USH1NJ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H400-H410
Precautionary statements  P264-P270-P273-P301+P312-P330-P391-P501
NFPA 704
0
2 0

Vipadenant price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20239 Vipadenant ≥98% 442908-10-3 500μg $68 2024-03-01 Buy
Cayman Chemical 20239 Vipadenant ≥98% 442908-10-3 1mg $121 2024-03-01 Buy
Cayman Chemical 20239 Vipadenant ≥98% 442908-10-3 5mg $469 2024-03-01 Buy
TRC V670808 Vipadenant 442908-10-3 50mg $1440 2021-12-16 Buy
TRC V670808 Vipadenant 442908-10-3 5mg $255 2021-12-16 Buy
Product number Packaging Price Buy
20239 500μg $68 Buy
20239 1mg $121 Buy
20239 5mg $469 Buy
V670808 50mg $1440 Buy
V670808 5mg $255 Buy

Vipadenant Chemical Properties,Uses,Production

Description

Vipadenant (also known as BIIB014) is a potent, selective oral adenosine A2A receptor antagonist under development for the treatment of Parkinson’s disease. It has successfully completed phase I clinical studies. It might also be a potential adjunctive therapy reagent for cancer treatment. It was found that it has certain potentials to disrupt an immunosuppressive mechanism of tumour protection, generating improved efficacy for immunotherapies of certain cancers when used in combination with other drugs.

References

http://www.medkoo.com/products/8047
Shook, B. C., and P. F. Jackson. "Adenosine A(2A) Receptor Antagonists and Parkinson's Disease. " Acs Chemical Neuroscience2.10(2011):555-67.
Brooks, D. J., et al. "An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers." Clinical Neuropharmacology 33.2(2010):55.
http://www.vernalis.com/nce-pipeline/oncology/v2006

Uses

Vipadenant is a potent, selective and orally available adenosine A2A receptor antagonist under development for for Parkinson''s disease. Vipadenant demonstrates strong oral activity in commonly used models of Parkinson''s disease. Vipadenant has shown excellent preclinical pharmacokinetics and has successfully completed phase I clinical studies.

in vivo

Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen[1]. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats[2].

442908-07-8
442908-10-3
Synthesis of Vipadenant from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

Vipadenant Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 77)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32222 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58

View Lastest Price from Vipadenant manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vipadenant pictures 2020-01-02 Vipadenant
442908-10-3
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • Vipadenant pictures
  • Vipadenant
    442908-10-3
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

442908-10-3(Vipadenant)Related Search:

Vipadenant(BIIB 014) 3-[(4-Amino-3-methylphenyl)methyl]-7-(2-furanyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine CEB 4520 V 2006 VER 11135 VER-A 00049 VER-A 00-11 VER-ADO 49 BIIB 014 Vipadenant 5-BROMO-4-(METHYLSULFANYL)-1H-PYRROLO[2,3-B]PYRIDINE 3H-1,2,3-Triazolo[4,5-d]pyrimidin-5-amine, 3-[(4-amino-3-methylphenyl)methyl]-7-(2-furanyl)- BIIB-014 Vipadenant BIIB-014;BIIB 014;BIIB014 CS-2294 3-[(4-amino-3-methylphenyl)methyl]-7-(furan-2-yl)triazolo[4,5-d]pyrimidin-5-amine 3-(4-AMINO-3-METHYLBENZYL)-7-(FURAN-2-YL)-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-5- AMINE CEB 4520,Vipadenant,BIIB 014,BIIB014,CEB4520,inhibit,Adenosine Receptor,Inhibitor,P1 receptor BIIB-014, CEB-4520 Vipadenant, 10 mM in DMSO 442908-10-3 C16H15N7O Inhibitors API